Nuclear Receptor Coactivator 1 MeSH Descriptor Data 2025

MeSH Heading: Nuclear Receptor Coactivator 1
Tree Number(s): D08.811.913.050.134.415.500.100; D12.644.360.024.314.100; D12.776.157.057.080.100; D12.776.260.103.782; D12.776.476.024.394.100; D12.776.660.675.100; D12.776.930.125.500.625; D12.776.930.617.100
Unique ID: D056920
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D056920
Scope Note: A nuclear receptor coactivator with specificity for ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and THYROID HORMONE RECEPTORS. It contains a HISTONE ACETYLTRANSFRASE activity that may play a role in the transcriptional activation of CHROMATIN regions.
Entry Term(s): NCoA-1 Protein; Nuclear Receptor Coactivator-1; Steroid Receptor Coactivator 1
Registry Numbers: EC 2.3.1.48
Public MeSH Note: 2010; NUCLEAR RECEPTOR COACTIVATOR 1 was indexed under TRANSCRIPTION FACTORS and HISTONE ACETYLTRANSFERASES 1995-2009
History Note: 2010(1995)
Date Established: 2010/01/01
Date of Entry: 2009/07/06
Revision Date: 2016/04/15

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Acyltransferases [D08.811.913.050]
      - Acetyltransferases [D08.811.913.050.134]
        
        Lysine Acetyltransferases [D08.811.913.050.134.415]
        
        Histone Acetyltransferases [D08.811.913.050.134.415.500]
        
        CLOCK Proteins [D08.811.913.050.134.415.500.049]
        
        Lysine Acetyltransferase 5 [D08.811.913.050.134.415.500.062]
        
        N-Terminal Acetyltransferase D [D08.811.913.050.134.415.500.074]
        
        Nuclear Receptor Coactivator 1 [D08.811.913.050.134.415.500.100]
        
        Nuclear Receptor Coactivator 3 [D08.811.913.050.134.415.500.150]
        
        p300-CBP Transcription Factors [D08.811.913.050.134.415.500.575]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intracellular Signaling Peptides and Proteins [D12.644.360]
    - Adaptor Proteins, Signal Transducing [D12.644.360.024]
      - Nuclear Receptor Coactivators [D12.644.360.024.314]
        
        Mediator Complex Subunit 1 [D12.644.360.024.314.049]
        
        Nuclear Receptor Coactivator 1 [D12.644.360.024.314.100]
        
        Nuclear Receptor Coactivator 2 [D12.644.360.024.314.200]
        
        Nuclear Receptor Coactivator 3 [D12.644.360.024.314.300]
        
        Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha [D12.644.360.024.314.650]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Adaptor Proteins, Signal Transducing [D12.776.157.057]
      - Nuclear Receptor Coactivators [D12.776.157.057.080]
        
        Mediator Complex Subunit 1 [D12.776.157.057.080.049]
        
        Nuclear Receptor Coactivator 1 [D12.776.157.057.080.100]
        
        Nuclear Receptor Coactivator 2 [D12.776.157.057.080.200]
        
        Nuclear Receptor Coactivator 3 [D12.776.157.057.080.300]
        
        Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha [D12.776.157.057.080.650]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - DNA-Binding Proteins [D12.776.260]
    - Basic Helix-Loop-Helix Transcription Factors [D12.776.260.103]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Adaptor Proteins, Signal Transducing [D12.776.476.024]
      - Nuclear Receptor Coactivators [D12.776.476.024.394]
        
        Mediator Complex Subunit 1 [D12.776.476.024.394.049]
        
        Nuclear Receptor Coactivator 1 [D12.776.476.024.394.100]
        
        Nuclear Receptor Coactivator 2 [D12.776.476.024.394.200]
        
        Nuclear Receptor Coactivator 3 [D12.776.476.024.394.300]
        
        Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha [D12.776.476.024.394.650]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Nuclear Proteins [D12.776.660]
    - Nuclear Receptor Coactivators [D12.776.660.675]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Transcription Factors [D12.776.930]
    - Basic Helix-Loop-Helix Transcription Factors [D12.776.930.125]
      - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [D12.776.930.125.500]
        
        Microphthalmia-Associated Transcription Factor [D12.776.930.125.500.500]
        
        N-Myc Proto-Oncogene Protein [D12.776.930.125.500.563]
        
        Nuclear Receptor Coactivator 1 [D12.776.930.125.500.625]
        
        Sterol Regulatory Element Binding Proteins [D12.776.930.125.500.750]
        
        Transcription Factor 3 [D12.776.930.125.500.875]
        
        Transcription Factor 4 [D12.776.930.125.500.937]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Transcription Factors [D12.776.930]
    - Nuclear Receptor Coactivators [D12.776.930.617]

Nuclear Receptor Coactivator 1 Preferred

Concept UI: M0533381
Registry Numbers: EC 2.3.1.48
Scope Note: A nuclear receptor coactivator with specificity for ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and THYROID HORMONE RECEPTORS. It contains a HISTONE ACETYLTRANSFRASE activity that may play a role in the transcriptional activation of CHROMATIN regions.
Terms: Nuclear Receptor Coactivator 1 Preferred Term
Term UI T746975
Date03/04/2009
LexicalTag NON
ThesaurusID NLM (2010); NCoA-1 Protein
Term UI T000896305
Date03/02/2016
LexicalTag ABX
ThesaurusID NLM (2017); Nuclear Receptor Coactivator-1
Term UI T746970
Date03/04/2009
LexicalTag NON
ThesaurusID NLM (2010); Steroid Receptor Coactivator 1
Term UI T746974
Date03/04/2009
LexicalTag NON
ThesaurusID NLM (2010)

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