MeSH Browser

MeSH Heading: Lysine Acetyltransferase 5
Tree Number(s): D08.811.913.050.134.415.500.062
Unique ID: D000074443
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000074443
Scope Note: A catalytic subunit of the NuA4 histone acetyltransferase complex that functions in transcriptional activation of genes by acetylation of nucleosomal HISTONES H4 and H2A, altering nucleosome-DNA interactions and interaction of the modified histones with other activating transcription factors. It may control gene expression changes associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest; CELL AGING; APOPTOSIS; and DNA REPAIR. It is polyubiquitinated and degraded during HIV-1 infection through its interaction with the viral TAT PROTEIN.
Entry Term(s): HIV-1-Tat Interactive Protein Tip60; HTATIP; KAT5 (TIP60) Protein
Registry Numbers: EC 2.3.1.48
Previous Indexing: Acetyltransferases (2002-2017); Histone Acetyltransferases (2005-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/04/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000626677
Registry Numbers: EC 2.3.1.48
Scope Note: A catalytic subunit of the NuA4 histone acetyltransferase complex that functions in transcriptional activation of genes by acetylation of nucleosomal HISTONES H4 and H2A, altering nucleosome-DNA interactions and interaction of the modified histones with other activating transcription factors. It may control gene expression changes associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest; CELL AGING; APOPTOSIS; and DNA REPAIR. It is polyubiquitinated and degraded during HIV-1 infection through its interaction with the viral TAT PROTEIN.
Terms: Lysine Acetyltransferase 5 Preferred Term
Term UI T000916090
Date02/21/2017
LexicalTag NON
ThesaurusID NLM (2018); HTATIP
Term UI T000916094
Date02/21/2017
LexicalTag ABB
ThesaurusID NLM (2018); KAT5 (TIP60) Protein
Term UI T000916092
Date02/21/2017
LexicalTag ABX
ThesaurusID NLM (2018); HIV-1-Tat Interactive Protein Tip60
Term UI T000916093
Date02/21/2017
LexicalTag ABX
ThesaurusID NLM (2018)

Lysine Acetyltransferase 5 MeSH Descriptor Data 2025