MeSH Browser

MeSH Heading: Apoptosis
Tree Number(s): G04.146.954.035
Unique ID: D017209
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D017209
Annotation: general or unspecified, note specifics
Scope Note: A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Entry Term(s): Apoptosis, Extrinsic Pathway; Apoptosis, Intrinsic Pathway; Caspase-Dependent Apoptosis; Classic Apoptosis; Classical Apoptosis; Programmed Cell Death; Programmed Cell Death, Type I
NLM Classification #: QU 375
Previous Indexing: Cell Survival (1972-1992)
See Also: CARD Signaling Adaptor Proteins; Caspases; Cellular Apoptosis Susceptibility Protein; Death Domain Receptor Signaling Adaptor Proteins; Genes, Transgenic, Suicide; In Situ Nick-End Labeling; Necrosis
Public MeSH Note: 93
History Note: 93
Date Established: 1993/01/01
Date of Entry: 1992/05/07
Revision Date: 2021/06/30

Allowable Qualifiers: drug effects (DE)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Concept UI: M0026116
Scope Note: A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Terms: Apoptosis Preferred Term
Term UI T051308
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1993); Classical Apoptosis
Term UI T000946887
Date09/18/2018
LexicalTag NON
ThesaurusID NLM (2020); Classic Apoptosis
Term UI T000946888
Date09/18/2018
LexicalTag NON
ThesaurusID NLM (2020); Programmed Cell Death, Type I
Term UI T615426
Date10/25/2004
LexicalTag NON
ThesaurusID NLM (2006)

Apoptosis MeSH Descriptor Data 2024