MeSH Browser

MeSH Heading: Receptors, Death Domain
Tree Number(s): D12.776.543.750.690
Unique ID: D053218
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D053218
Scope Note: A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a DEATH DOMAIN due to the fact that many of these receptors are involved in APOPTOSIS signaling pathways. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES.
Entry Version: RECEPT DEATH DOMAIN
Entry Term(s): Death Domain Receptors; Death Receptor; Death Receptors; Receptors, DR Family; Receptors, Death Domain Family
See Also: Receptors, Tumor Necrosis Factor
Public MeSH Note: 2007
History Note: 2007
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Concept UI: M0492026
Scope Note: A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a DEATH DOMAIN due to the fact that many of these receptors are involved in APOPTOSIS signaling pathways. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES.
Terms: Receptors, Death Domain Preferred Term
Term UI T659925
Date11/25/2005
LexicalTag NON
ThesaurusID NLM (2007); Death Receptor
Term UI T001004258
Date12/27/2019
LexicalTag NON
ThesaurusID NLM (2021); Receptors, Death Domain Family
Term UI T659926
Date11/25/2005
LexicalTag NON
ThesaurusID NLM (2007); Receptors, DR Family
Term UI T659927
Date11/25/2005
LexicalTag ABX
ThesaurusID NLM (2007); Death Domain Receptors
Term UI T659928
Date11/25/2005
LexicalTag NON
ThesaurusID NLM (2007); Death Receptors
Term UI T659929
Date11/25/2005
LexicalTag NON
ThesaurusID NLM (2007)

Receptors, Death Domain MeSH Descriptor Data 2025