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fas Receptor MeSH Descriptor Data 2023

MeSH Heading
fas Receptor
Tree Number(s)
Unique ID
RDF Unique Identifier
Scope Note
A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. Mutations in the CD95 gene are associated with cases of autoimmune lymphoproliferative syndrome.
Entry Version
Entry Term(s)
APO-1 Antigen
Antigens, CD95
CD95 Antigen
CD95 Antigens
Fas Cell Surface Death Receptor
Receptors, fas
TNFRSF6 Receptor
Tumor Necrosis Factor Receptor Superfamily, Member 6
fas Antigen
fas Antigens
fas Receptors
Registry Number
Previous Indexing
Antigens, Surface (1989-1995)
See Also
Autoimmune Lymphoproliferative Syndrome
Public MeSH Note
2018; see ANTIGENS, CD95 1989-2017; FAS ANTIGEN was indexed under ANTIGENS, SURFACE 1989-1995; FAS RECEPTOR was indexed under RECEPTORS, TUMOR NECROSIS FACTOR 1998-1999
History Note
2018 (1989)
Date Established
Date of Entry
Revision Date
fas Receptor Preferred
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