MeSH Browser

MeSH Heading: Receptors, Tumor Necrosis Factor, Type I
Tree Number(s): D12.776.543.750.690.750; D12.776.543.750.705.852.760.597
Unique ID: D047888
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D047888
Scope Note: A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. It is constitutively expressed in most tissues and is a key mediator of tumor necrosis factor signaling in the vast majority of cells. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
Entry Version: RECEPT TUMOR NECROSIS FACTOR TYPE I
Entry Term(s): Antigens, CD120a; CD 120a Antigen; CD120a Antigen; CD120a Antigens; Receptors, Tumor Necrosis Factor, Member 1A; TNFR p60; TNFR-I; TNFR1; TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily, Member 1A); TNFRSF1A Receptor; Tumor Necrosis Factor Receptor 1A; Tumor Necrosis Factor Receptor Superfamily, Member 1A; Tumor Necrosis Factor Receptor Type 1; Tumor Necrosis Factor Receptor Type I
Previous Indexing: Antigens, CD (1994-2004); Tumor Necrosis Factor Receptors (1994-2004)
Public MeSH Note: 2005; TUMOR NECROSIS FACTOR RECEPTOR TYPE I (now RECEPTORS, TUMOR NECROSIS FACTOR TYPE I) was indexed under ANTIGENS, CD & TUMOR NECROSIS FACTOR RECEPTORS 1994-2004
History Note: 2005(1994)
Date Established: 2005/01/01
Date of Entry: 2004/07/15
Revision Date: 2017/05/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Death Domain [D12.776.543.750.690]
        
        fas Receptor [D12.776.543.750.690.500]
        
        Edar Receptor [D12.776.543.750.690.550]
        
        Receptors, TNF-Related Apoptosis-Inducing Ligand [D12.776.543.750.690.600]
        
        Receptors, Tumor Necrosis Factor, Member 25 [D12.776.543.750.690.725]
        
        Receptors, Tumor Necrosis Factor, Type I [D12.776.543.750.690.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Immunologic [D12.776.543.750.705]
        
        Receptors, Cytokine [D12.776.543.750.705.852]
        
        Receptors, Tumor Necrosis Factor [D12.776.543.750.705.852.760]
        
        Tumor Necrosis Factor Receptor Superfamily, Member 7 [D12.776.543.750.705.852.760.048]
        
        Ki-1 Antigen [D12.776.543.750.705.852.760.072]
        
        CD40 Antigens [D12.776.543.750.705.852.760.097]
        
        fas Receptor [D12.776.543.750.705.852.760.195]
        
        Tumor Necrosis Factor Receptor Superfamily, Member 9 [D12.776.543.750.705.852.760.220]
        
        B-Cell Activation Factor Receptor [D12.776.543.750.705.852.760.222]
        
        B-Cell Maturation Antigen [D12.776.543.750.705.852.760.226]
        
        Etanercept [D12.776.543.750.705.852.760.232]
        
        Glucocorticoid-Induced TNFR-Related Protein [D12.776.543.750.705.852.760.238]
        
        Lymphotoxin beta Receptor [D12.776.543.750.705.852.760.245]
        
        Receptor Activator of Nuclear Factor-kappa B [D12.776.543.750.705.852.760.345]
        
        Receptors, Ectodysplasin [D12.776.543.750.705.852.760.347]
        
        Receptors, OX40 [D12.776.543.750.705.852.760.350]
        
        Receptors, TNF-Related Apoptosis-Inducing Ligand [D12.776.543.750.705.852.760.396]
        
        Receptors, Tumor Necrosis Factor, Member 14 [D12.776.543.750.705.852.760.500]
        
        Receptors, Tumor Necrosis Factor, Member 25 [D12.776.543.750.705.852.760.505]
        
        Receptors, Tumor Necrosis Factor, Type I [D12.776.543.750.705.852.760.597]
        
        Receptors, Tumor Necrosis Factor, Type II [D12.776.543.750.705.852.760.798]
        
        Transmembrane Activator and CAML Interactor Protein [D12.776.543.750.705.852.760.899]
        
        Tumor Necrosis Factor Decoy Receptors [D12.776.543.750.705.852.760.949]
        
        TWEAK Receptor [D12.776.543.750.705.852.760.974]

Receptors, Tumor Necrosis Factor, Type I Preferred

Concept UI: M0232359
Scope Note: A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. It is constitutively expressed in most tissues and is a key mediator of tumor necrosis factor signaling in the vast majority of cells. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
Terms: Receptors, Tumor Necrosis Factor, Type I Preferred Term
Term UI T571091
Date02/02/2004
LexicalTag NON
ThesaurusID NLM (2005); CD120a Antigen
Term UI T262354
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2005); TNFR p60
Term UI T262360
Date01/01/1955
LexicalTag ABB
ThesaurusID NLM (2005); TNFR-I
Term UI T262361
Date01/01/1955
LexicalTag ABB
ThesaurusID NLM (2005); Tumor Necrosis Factor Receptor Type I
Term UI T262363
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2005); TNFR1
Term UI T372670
Date01/01/1955
LexicalTag ABB
ThesaurusID NLM (2005); Tumor Necrosis Factor Receptor 1A
Term UI T468872
Date11/06/2001
LexicalTag NON
ThesaurusID NLM (2005); TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily, Member 1A)
Term UI T468873
Date11/06/2001
LexicalTag ABX
ThesaurusID NLM (2005); Tumor Necrosis Factor Receptor Type 1
Term UI T571083
Date02/02/2004
LexicalTag NON
ThesaurusID NLM (2005); Antigens, CD120a
Term UI T571087
Date02/02/2004
LexicalTag ABX
ThesaurusID NLM (2005); CD120a Antigens
Term UI T571092
Date02/02/2004
LexicalTag ABX
ThesaurusID NLM (2005); TNFRSF1A Receptor
Term UI T572158
Date02/10/2004
LexicalTag NON
ThesaurusID NLM (2005); Tumor Necrosis Factor Receptor Superfamily, Member 1A
Term UI T572185
Date02/10/2004
LexicalTag NON
ThesaurusID NLM (2005); CD 120a Antigen
Term UI T262353
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2005); Receptors, Tumor Necrosis Factor, Member 1A
Term UI T660259
Date11/29/2005
LexicalTag NON
ThesaurusID NLM (2007)

Receptors, Tumor Necrosis Factor, Type I MeSH Descriptor Data 2025