MeSH Browser

MeSH Heading: Tumor Necrosis Factor-alpha
Tree Number(s): D09.400.430.965; D12.644.276.374.500.800; D12.644.276.374.750.626; D12.776.124.900; D12.776.395.930; D12.776.467.374.500.800; D12.776.467.374.750.626; D23.529.374.500.800; D23.529.374.750.626
Unique ID: D014409
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D014409
Scope Note: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Entry Term(s): Cachectin; Cachectin-Tumor Necrosis Factor; TNF Superfamily, Member 2; TNF-alpha; TNFalpha; Tumor Necrosis Factor; Tumor Necrosis Factor Ligand Superfamily Member 2
Previous Indexing: Endotoxins (1975-1987); Glycoproteins (1975-1987); Necrosis (1975-1987)
See Also: Adalimumab; Certolizumab Pegol; Infliximab
Public MeSH Note: 2005; see TUMOR NECROSIS FACTOR 1988-2005
History Note: 2005(1988)
Date Established: 1988/01/01
Date of Entry: 1987/05/08
Revision Date: 2023/03/16

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0022150
Scope Note: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Terms: Tumor Necrosis Factor-alpha Preferred Term
Term UI T042154
Date05/08/1987
LexicalTag NON
ThesaurusID UNK (19XX); TNF-alpha
Term UI T042152
Date05/08/1987
LexicalTag ABB
ThesaurusID UNK (19XX); Tumor Necrosis Factor
Term UI T042153
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1988); TNF Superfamily, Member 2
Term UI T660224
Date11/28/2005
LexicalTag NON
ThesaurusID NLM (2007); Tumor Necrosis Factor Ligand Superfamily Member 2
Term UI T661558
Date12/07/2005
LexicalTag NON
ThesaurusID NLM (2007); TNFalpha
Term UI T716352
Date03/17/2008
LexicalTag ABB
ThesaurusID NLM (2009); Cachectin-Tumor Necrosis Factor
Term UI T042151
Date05/08/1987
LexicalTag NON
ThesaurusID UNK (19XX); Cachectin
Term UI T042150
Date05/08/1987
LexicalTag NON
ThesaurusID UNK (19XX)

Tumor Necrosis Factor-alpha MeSH Descriptor Data 2025