MeSH Browser

MeSH Heading: Asialoglycoproteins
Tree Number(s): D09.400.430.657; D12.776.395.140
Unique ID: D001212
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D001212
Scope Note: Endogenous glycoproteins from which SIALIC ACID has been removed by the action of sialidases. They bind tightly to the ASIALOGLYCOPROTEIN RECEPTOR which is located on hepatocyte plasma membranes. After internalization by adsorptive ENDOCYTOSIS they are delivered to LYSOSOMES for degradation. Therefore receptor-mediated clearance of asialoglycoproteins is an important aspect of the turnover of plasma glycoproteins. They are elevated in serum of patients with HEPATIC CIRRHOSIS or HEPATITIS.
Entry Term(s): Asialoglycoprotein; Desialylated Glycoproteins
Previous Indexing: Glycoproteins (1966-1984)
See Also: Asialoglycoprotein Receptor
Public MeSH Note: 85
History Note: 85
Date Established: 1985/01/01
Date of Entry: 1984/05/30
Revision Date: 2023/03/16

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0001810
Scope Note: Endogenous glycoproteins from which SIALIC ACID has been removed by the action of sialidases. They bind tightly to the ASIALOGLYCOPROTEIN RECEPTOR which is located on hepatocyte plasma membranes. After internalization by adsorptive ENDOCYTOSIS they are delivered to LYSOSOMES for degradation. Therefore receptor-mediated clearance of asialoglycoproteins is an important aspect of the turnover of plasma glycoproteins. They are elevated in serum of patients with HEPATIC CIRRHOSIS or HEPATITIS.
Terms: Asialoglycoproteins Preferred Term
Term UI T003612
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1985); Asialoglycoprotein
Term UI T001085930
Date08/03/2020
LexicalTag NON
ThesaurusID NLM (2022); Desialylated Glycoproteins
Term UI T003613
Date05/30/1984
LexicalTag NON
ThesaurusID UNK (19XX)

Asialoglycoproteins MeSH Descriptor Data 2025