4-1BB Ligand MeSH Descriptor Data 2025

MeSH Heading: 4-1BB Ligand
Tree Number(s): D09.400.430.685; D12.644.276.374.750.065; D12.776.395.192; D12.776.467.374.750.065; D12.776.543.550.194; D23.529.374.750.065
Unique ID: D053330
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D053330
Scope Note: A membrane bound member of the TNF superfamily that is expressed on activated B-LYMPHOCYTES; MACROPHAGES; and DENDRITIC CELLS. The ligand is specific for the 4-1BB RECEPTOR and may play a role in inducing the proliferation of activated peripheral blood T-LYMPHOCYTES.
Entry Term(s): 4-1BBL Protein; CD137 Ligand; Tumor Necrosis Factor (Ligand) Superfamily, Member 9; Tumor Necrosis Factor Ligand Superfamily Member 9
Public MeSH Note: 2007; 4-1BB LIGAND was indexed under TUMOR NECROSIS FACTORS 2006 & under TUMOR NECROSIS FACTOR-ALPHA 1998-2005
History Note: 2007(1998)
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2023/03/16

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Carbohydrates [D09]
- Glycoconjugates [D09.400]
  - Glycoproteins [D09.400.430]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intercellular Signaling Peptides and Proteins [D12.644.276]
    - Cytokines [D12.644.276.374]
      - Tumor Necrosis Factors [D12.644.276.374.750]
        
        CD27 Ligand [D12.644.276.374.750.030]
        
        B-Cell Activating Factor [D12.644.276.374.750.061]
        
        4-1BB Ligand [D12.644.276.374.750.065]
        
        CD30 Ligand [D12.644.276.374.750.092]
        
        CD40 Ligand [D12.644.276.374.750.124]
        
        Cytokine TWEAK [D12.644.276.374.750.155]
        
        Ectodysplasins [D12.644.276.374.750.186]
        
        Fas Ligand Protein [D12.644.276.374.750.249]
        
        Lymphotoxin-alpha [D12.644.276.374.750.500]
        
        Lymphotoxin alpha1, beta2 Heterotrimer [D12.644.276.374.750.505]
        
        Lymphotoxin-beta [D12.644.276.374.750.515]
        
        OX40 Ligand [D12.644.276.374.750.531]
        
        RANK Ligand [D12.644.276.374.750.562]
        
        TNF-Related Apoptosis-Inducing Ligand [D12.644.276.374.750.625]
        
        Tumor Necrosis Factor-alpha [D12.644.276.374.750.626]
        
        Tumor Necrosis Factor Ligand Superfamily Member 13 [D12.644.276.374.750.656]
        
        Tumor Necrosis Factor Ligand Superfamily Member 14 [D12.644.276.374.750.690]
        
        Tumor Necrosis Factor Ligand Superfamily Member 15 [D12.644.276.374.750.720]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Glycoproteins [D12.776.395]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intercellular Signaling Peptides and Proteins [D12.776.467]
    - Cytokines [D12.776.467.374]
      - Tumor Necrosis Factors [D12.776.467.374.750]
        
        CD27 Ligand [D12.776.467.374.750.030]
        
        B-Cell Activating Factor [D12.776.467.374.750.061]
        
        4-1BB Ligand [D12.776.467.374.750.065]
        
        CD30 Ligand [D12.776.467.374.750.092]
        
        CD40 Ligand [D12.776.467.374.750.124]
        
        Cytokine TWEAK [D12.776.467.374.750.155]
        
        Ectodysplasins [D12.776.467.374.750.186]
        
        Fas Ligand Protein [D12.776.467.374.750.249]
        
        Lymphotoxin-alpha [D12.776.467.374.750.500]
        
        Lymphotoxin alpha1, beta2 Heterotrimer [D12.776.467.374.750.505]
        
        Lymphotoxin-beta [D12.776.467.374.750.515]
        
        OX40 Ligand [D12.776.467.374.750.531]
        
        RANK Ligand [D12.776.467.374.750.562]
        
        TNF-Related Apoptosis-Inducing Ligand [D12.776.467.374.750.625]
        
        Tumor Necrosis Factor-alpha [D12.776.467.374.750.626]
        
        Tumor Necrosis Factor Ligand Superfamily Member 13 [D12.776.467.374.750.656]
        
        Tumor Necrosis Factor Ligand Superfamily Member 14 [D12.776.467.374.750.690]
        
        Tumor Necrosis Factor Ligand Superfamily Member 15 [D12.776.467.374.750.710]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]

Biological Factors [D23]
- Intercellular Signaling Peptides and Proteins [D23.529]
  - Cytokines [D23.529.374]
    - Tumor Necrosis Factors [D23.529.374.750]

4-1BB Ligand Preferred

Concept UI: M0291679
Scope Note: A membrane bound member of the TNF superfamily that is expressed on activated B-LYMPHOCYTES; MACROPHAGES; and DENDRITIC CELLS. The ligand is specific for the 4-1BB RECEPTOR and may play a role in inducing the proliferation of activated peripheral blood T-LYMPHOCYTES.
Terms: 4-1BB Ligand Preferred Term
Term UI T321684
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2007); Tumor Necrosis Factor Ligand Superfamily Member 9
Term UI T661600
Date12/07/2005
LexicalTag NON
ThesaurusID NLM (2007); 4-1BBL Protein
Term UI T661601
Date12/07/2005
LexicalTag ABX
ThesaurusID NLM (2007); Tumor Necrosis Factor (Ligand) Superfamily, Member 9
Term UI T661602
Date12/07/2005
LexicalTag NON
ThesaurusID NLM (2007); CD137 Ligand
Term UI T661610
Date12/07/2005
LexicalTag ABX
ThesaurusID NLM (2007)

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