MeSH Browser

MeSH Heading: Signaling Lymphocytic Activation Molecule Family
Tree Number(s): D09.400.430.890.736; D12.776.395.550.736; D12.776.543.550.746; D12.776.543.750.705.970
Unique ID: D000071176
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071176
Scope Note: Type-I membrane glycoproteins that are expressed primarily on the surface of CD4 or CD8-positive T-CELLS; NATURAL KILLER CELLS; and some populations of B CELLS. They are characterized by an N-terminal, extracellular IMMUNOGLOBULIN-LIKE DOMAIN and a membrane-proximal IMMUNOGLOBULIN C2-SET DOMAIN. SLAMF receptors typically signal through homophilic interactions and are important for mediating the immune response and immune cell differentiation.
Entry Term(s): SLAM Family Receptors; SLAMF Receptors; Signaling Lymphocytic Activation Molecule Family Receptors; Signaling Lymphocytic Activation Molecule Receptors; Signaling Lymphocytic Activation Molecules
Previous Indexing: Antigens, CD (1997-2016); Receptors, Cell Surface (1997-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2023/03/16

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Carbohydrates [D09]
- Glycoconjugates [D09.400]
  - Glycoproteins [D09.400.430]
    - Membrane Glycoproteins [D09.400.430.890]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Glycoproteins [D12.776.395]
    - Membrane Glycoproteins [D12.776.395.550]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Immunologic [D12.776.543.750.705]
        
        Lymphocyte Activation Gene 3 Protein [D12.776.543.750.705.012]
        
        Leukocyte Immunoglobulin-like Receptor B1 [D12.776.543.750.705.023]
        
        Lipopolysaccharide Receptors [D12.776.543.750.705.045]
        
        Costimulatory and Inhibitory T-Cell Receptors [D12.776.543.750.705.222]
        
        Immunophilins [D12.776.543.750.705.400]
        
        Integrins [D12.776.543.750.705.408]
        
        Platelet Membrane Glycoproteins [D12.776.543.750.705.675]
        
        Receptors, Antigen [D12.776.543.750.705.816]
        
        Receptors, Complement [D12.776.543.750.705.833]
        
        Receptors, Cytokine [D12.776.543.750.705.852]
        
        Receptors, Fc [D12.776.543.750.705.871]
        
        Receptors, Formyl Peptide [D12.776.543.750.705.873]
        
        Receptors, Laminin [D12.776.543.750.705.876]
        
        Receptors, Lymphocyte Homing [D12.776.543.750.705.877]
        
        Receptors, Mitogen [D12.776.543.750.705.880]
        
        Receptors, Natural Killer Cell [D12.776.543.750.705.895]
        
        Receptors, Pattern Recognition [D12.776.543.750.705.910]
        
        Receptors, Scavenger [D12.776.543.750.705.940]
        
        Signaling Lymphocytic Activation Molecule Family [D12.776.543.750.705.970]
        
        CD48 Antigen [D12.776.543.750.705.970.250]
        
        Signaling Lymphocytic Activation Molecule Family Member 1 [D12.776.543.750.705.970.500]
        
        Triggering Receptor Expressed on Myeloid Cells-1 [D12.776.543.750.705.985]

Signaling Lymphocytic Activation Molecule Family Preferred

Concept UI: M000613385
Scope Note: Type-I membrane glycoproteins that are expressed primarily on the surface of CD4 or CD8-positive T-CELLS; NATURAL KILLER CELLS; and some populations of B CELLS. They are characterized by an N-terminal, extracellular IMMUNOGLOBULIN-LIKE DOMAIN and a membrane-proximal IMMUNOGLOBULIN C2-SET DOMAIN. SLAMF receptors typically signal through homophilic interactions and are important for mediating the immune response and immune cell differentiation.
Terms: Signaling Lymphocytic Activation Molecule Family Preferred Term
Term UI T000894625
Date02/04/2016
LexicalTag NON
ThesaurusID NLM (2017); Signaling Lymphocytic Activation Molecules
Term UI T000893269
Date01/07/2016
LexicalTag NON
ThesaurusID NLM (2017); SLAM Family Receptors
Term UI T000893270
Date01/07/2016
LexicalTag ACX
ThesaurusID NLM (2017); SLAMF Receptors
Term UI T000893271
Date01/07/2016
LexicalTag ABX
ThesaurusID NLM (2017); Signaling Lymphocytic Activation Molecule Family Receptors
Term UI T000894626
Date02/04/2016
LexicalTag NON
ThesaurusID NLM (2017); Signaling Lymphocytic Activation Molecule Receptors
Term UI T000894627
Date02/04/2016
LexicalTag NON
ThesaurusID NLM (2017)

Signaling Lymphocytic Activation Molecule Family MeSH Descriptor Data 2025