Members of a family of highly conserved proteins which are all cis-trans peptidyl-prolyl isomerases (PEPTIDYLPROLYL ISOMERASE). They bind the immunosuppressant drugs CYCLOSPORINE; TACROLIMUS and SIROLIMUS. They possess rotamase activity, which is inhibited by the immunosuppressant drugs that bind to them.
Entry Term(s)
Immunophilin
Neurophilin
Neurophilins
Registry Number
EC 5.2.1.8
Related Numbers
EC 5.2.1.8
Previous Indexing
Immunosuppressive Agents (1990-1998)
Public MeSH Note
2004; NEUROPHILIN was indexed under LYMPHOKINES 1974-2003; ENDOTHELIAL GROWTH FACTORS 1991-2003 & INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS 2002
History Note
2004(1999); for NEUROPHILIN use VASCULAR ENDOTHELIAL GROWTH FACTOR (NM) 1997-2003
Members of a family of highly conserved proteins which are all cis-trans peptidyl-prolyl isomerases (PEPTIDYLPROLYL ISOMERASE). They bind the immunosuppressant drugs CYCLOSPORINE; TACROLIMUS and SIROLIMUS. They possess rotamase activity, which is inhibited by the immunosuppressant drugs that bind to them.
