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Sirolimus MeSH Descriptor Data 2022


MeSH Heading
Sirolimus
Tree Number(s)
D02.540.505.760
Unique ID
D020123
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D020123
Scope Note
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
Entry Term(s)
AY 22-989
I-2190A
Rapamune
Rapamycin
Pharm Action
Anti-Bacterial Agents
Antibiotics, Antineoplastic
Antifungal Agents
Immunosuppressive Agents
Registry Number
W36ZG6FT64
Related Numbers
53123-88-9
Previous Indexing
Polyenes (1976-1998)
Public MeSH Note
99; RAPAMYCIN (now SIROLIMUS) was indexed under POLYENES 1976-98
History Note
99; use SIROLIMUS (NM) 1980-97
Date Established
1999/01/01
Date of Entry
1998/06/11
Revision Date
2016/07/01
Sirolimus Preferred
I-2190A Narrower
AY 22-989 Narrower
Rapamune Narrower
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