MeSH Browser

MeSH Heading: Immunosuppressive Agents
Tree Number(s): D27.505.696.477.656
Unique ID: D007166
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007166
Scope Note: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Entry Term(s): Immunosuppressant; Immunosuppressants; Immunosuppressive Agent
NLM Classification #: QW 955
See Also: Antilymphocyte Serum; Antirheumatic Agents
Public MeSH Note: 66
History Note: 66(64)
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0011171
Scope Note: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Terms: Immunosuppressive Agents Preferred Term
Term UI T021500
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1964); Immunosuppressive Agent
Term UI T000997410
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021); Immunosuppressant
Term UI T000996294
Date11/14/2019
LexicalTag NON
ThesaurusID NLM (2021); Immunosuppressants
Term UI T021501
Date10/26/1994
LexicalTag NON
ThesaurusID NLM (1996)

Immunosuppressive Agents MeSH Descriptor Data 2025