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Neuropilins MeSH Descriptor Data 2023


MeSH Heading
Neuropilins
Tree Number(s)
D12.776.543.750.590
Unique ID
D039921
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D039921
Scope Note
Neuropilins are 140-kDa vertebrate cell surface receptors that bind neuronal guidance molecules during neural development and axonal outgrowth, and modulate VEGF-mediated angiogenesis. NEUROPILIN-1 and NEUROPILIN-2 differ in their binding specificities, and are distributed complementarily in regions of the developing nervous system. Neuropilins are receptors for secreted CLASS 3 SEMAPHORINS as well as for vascular endothelial growth factors, and may form hetero- or homodimers. They may also interact synergistically with plexins and with VEGF RECEPTORS to form receptor complexes with distinct affinities and specificities. Neuropilin binding specificity is determined by CUB and coagulation-factor-like domains in the extracellular portion of the molecule, while a MAM domain is essential for SIGNAL TRANSDUCTION.
Entry Term(s)
Neuropilin
Registry Number
0
Previous Indexing
Nerve Tissue Proteins (1998-2002)
Public MeSH Note
2003; NEUROPILIN was indexed under NERVE TISSUE PROTEINS 1998-2002
History Note
2003; for NEUROPILIN use NEUROPILIN-1 (NM) 1998-2002
Date Established
2003/01/01
Date of Entry
2002/07/03
Revision Date
2016/05/31
Neuropilins Preferred
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