MeSH Browser

MeSH Heading: Neuropilin-2
Tree Number(s): D12.776.543.750.590.750
Unique ID: D039943
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D039943
Scope Note: Transmembrane receptor for CLASS 3 SEMAPHORINS and several vascular endothelial growth factor isoforms. Neuropilin-2 functions either as a homodimer or as a heterodimer with NEUROPILIN-1. The binding affinity of neuropilin-2 varies for different class 3 semaphorin isoforms and is dependent on the composition of the dimer. The protein also forms receptor complexes with plexins and with VEGF RECEPTORS, which alters the binding characteristics of the receptor.
Entry Term(s): NRP2 Protein; Npn-2 Protein
Previous Indexing: Nerve Tissue Proteins (1998-2002)
Public MeSH Note: 2003; NPN-2 PROTEIN was indexed under NERVE TISSUE PROTEINS 1998-2002
History Note: 2003; for NPN-2 PROTEIN use NEUROPILIN-1 1998-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2016/05/31

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Concept UI: M0377884
Scope Note: Transmembrane receptor for CLASS 3 SEMAPHORINS and several vascular endothelial growth factor isoforms. Neuropilin-2 functions either as a homodimer or as a heterodimer with NEUROPILIN-1. The binding affinity of neuropilin-2 varies for different class 3 semaphorin isoforms and is dependent on the composition of the dimer. The protein also forms receptor complexes with plexins and with VEGF RECEPTORS, which alters the binding characteristics of the receptor.
Terms: Neuropilin-2 Preferred Term
Term UI T435157
Date02/03/2001
LexicalTag NON
ThesaurusID NLM (2003); Npn-2 Protein
Term UI T221841
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2003); NRP2 Protein
Term UI T435158
Date02/03/2001
LexicalTag ACX
ThesaurusID NLM (2003)

Neuropilin-2 MeSH Descriptor Data 2025