MeSH Browser

MeSH Heading: Receptors, Vascular Endothelial Growth Factor
Tree Number(s): D08.811.913.696.620.682.725.400.950; D12.776.476.568.400.950; D12.776.543.750.630.750; D12.776.543.750.750.400.910
Unique ID: D040262
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D040262
Annotation: general; prefer specifics
Scope Note: A family of closely related RECEPTOR PROTEIN-TYROSINE KINASES that bind vascular endothelial growth factors. They share a cluster of seven extracellular IG-LIKE DOMAINS which are important for ligand binding. They are highly expressed in vascular endothelial cells and are critical for the physiological and pathological growth, development and maintenance of blood and lymphatic vessels.
Entry Version: RECEPT VASCULAR ENDOTHELIAL GROWTH FACTOR
Entry Term(s): Endothelial Growth Factor Receptor; Receptor, Endothelial Growth Factors; Receptor, Vascular Endothelial Cell Growth Factor; Receptor, Vascular Permeability Factor; VEGF Receptor; VEGF Receptors; VPF Receptor; Vascular Endothelial Cell Growth Factor Receptor; Vascular Endothelial Growth Factor Receptor; Vascular Permeability Factor Receptor
Previous Indexing: Protein-Tyrosine Kinase (1993); Receptor Protein-Tyrosine Kinases (1994-2002); Receptors, Growth Factor (1993-2002); Receptors, Mitogen (1991-1992)
See Also: Bevacizumab; Immunoglobulin Domains
Public MeSH Note: 2003; VASCULAR ENDOTHELIAL CELL GROWTH FACTOR RECEPTOR (now RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR) was indexed under RECEPTORS, GROWTH FACTOR 1993-2002, RECEPTORS PROTEIN-TYROSINE KINASES 1994-2002, PROTEIN-TYROSINE KINASE 1993 & RECEPTORS, MITOGEN 1991-1992; ENDOTHELIAL GROWTH FACTOR RECEPTOR was indexed under RECEPTORS, MITOGEN & RECEPTORS, GROWTH FACTOR 1985-2003
History Note: 2003; use RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR (NM) 1991-2002; for ENDOTHELIAL GROWTH FACTOR RECEPTOR use RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR (NM) 1985-2003
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
        
        Receptor Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.400]
        
        Anaplastic Lymphoma Kinase [D08.811.913.696.620.682.725.400.002]
        
        c-Mer Tyrosine Kinase [D08.811.913.696.620.682.725.400.003]
        
        Discoidin Domain Receptors [D08.811.913.696.620.682.725.400.005]
        
        ErbB Receptors [D08.811.913.696.620.682.725.400.009]
        
        fms-Like Tyrosine Kinase 3 [D08.811.913.696.620.682.725.400.020]
        
        Proto-Oncogene Proteins c-kit [D08.811.913.696.620.682.725.400.050]
        
        Proto-Oncogene Proteins c-met [D08.811.913.696.620.682.725.400.075]
        
        Proto-Oncogene Proteins c-ret [D08.811.913.696.620.682.725.400.087]
        
        Receptor Tyrosine Kinase-like Orphan Receptors [D08.811.913.696.620.682.725.400.093]
        
        Receptor, Fibroblast Growth Factor, Type 1 [D08.811.913.696.620.682.725.400.177]
        
        Receptor, Fibroblast Growth Factor, Type 2 [D08.811.913.696.620.682.725.400.178]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D08.811.913.696.620.682.725.400.179]
        
        Receptor, Fibroblast Growth Factor, Type 4 [D08.811.913.696.620.682.725.400.180]
        
        Receptor, IGF Type 1 [D08.811.913.696.620.682.725.400.185]
        
        Receptor, Insulin [D08.811.913.696.620.682.725.400.200]
        
        Receptor, Macrophage Colony-Stimulating Factor [D08.811.913.696.620.682.725.400.500]
        
        Receptor, trkA [D08.811.913.696.620.682.725.400.660]
        
        Receptor, trkB [D08.811.913.696.620.682.725.400.700]
        
        Receptor, trkC [D08.811.913.696.620.682.725.400.800]
        
        Receptors, Eph Family [D08.811.913.696.620.682.725.400.850]
        
        Receptors, Platelet-Derived Growth Factor [D08.811.913.696.620.682.725.400.900]
        
        Receptors, TIE [D08.811.913.696.620.682.725.400.925]
        
        Receptors, Vascular Endothelial Growth Factor [D08.811.913.696.620.682.725.400.950]
        
        Vascular Endothelial Growth Factor Receptor-1 [D08.811.913.696.620.682.725.400.950.100]
        
        Vascular Endothelial Growth Factor Receptor-2 [D08.811.913.696.620.682.725.400.950.200]
        
        Vascular Endothelial Growth Factor Receptor-3 [D08.811.913.696.620.682.725.400.950.300]
        
        Axl Receptor Tyrosine Kinase [D08.811.913.696.620.682.725.400.975]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein-Tyrosine Kinases [D12.776.476.568]
      - Receptor Protein-Tyrosine Kinases [D12.776.476.568.400]
        
        Anaplastic Lymphoma Kinase [D12.776.476.568.400.002]
        
        c-Mer Tyrosine Kinase [D12.776.476.568.400.003]
        
        Discoidin Domain Receptors [D12.776.476.568.400.005]
        
        ErbB Receptors [D12.776.476.568.400.009]
        
        fms-Like Tyrosine Kinase 3 [D12.776.476.568.400.020]
        
        Proto-Oncogene Proteins c-kit [D12.776.476.568.400.050]
        
        Proto-Oncogene Proteins c-met [D12.776.476.568.400.075]
        
        Proto-Oncogene Proteins c-ret [D12.776.476.568.400.087]
        
        Receptor Tyrosine Kinase-like Orphan Receptors [D12.776.476.568.400.093]
        
        Receptor, Fibroblast Growth Factor, Type 1 [D12.776.476.568.400.177]
        
        Receptor, Fibroblast Growth Factor, Type 2 [D12.776.476.568.400.178]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D12.776.476.568.400.179]
        
        Receptor, Fibroblast Growth Factor, Type 4 [D12.776.476.568.400.180]
        
        Receptor, IGF Type 1 [D12.776.476.568.400.185]
        
        Receptor, Insulin [D12.776.476.568.400.200]
        
        Receptor, Macrophage Colony-Stimulating Factor [D12.776.476.568.400.500]
        
        Receptor, trkA [D12.776.476.568.400.660]
        
        Receptor, trkB [D12.776.476.568.400.700]
        
        Receptor, trkC [D12.776.476.568.400.800]
        
        Receptors, Eph Family [D12.776.476.568.400.850]
        
        Receptors, Platelet-Derived Growth Factor [D12.776.476.568.400.900]
        
        Receptors, TIE [D12.776.476.568.400.925]
        
        Receptors, Vascular Endothelial Growth Factor [D12.776.476.568.400.950]
        
        Vascular Endothelial Growth Factor Receptor-1 [D12.776.476.568.400.950.100]
        
        Vascular Endothelial Growth Factor Receptor-2 [D12.776.476.568.400.950.200]
        
        Vascular Endothelial Growth Factor Receptor-3 [D12.776.476.568.400.950.300]
        
        Axl Receptor Tyrosine Kinase [D12.776.476.568.400.975]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptor Protein-Tyrosine Kinases [D12.776.543.750.630]
        
        Anaplastic Lymphoma Kinase [D12.776.543.750.630.002]
        
        c-Mer Tyrosine Kinase [D12.776.543.750.630.003]
        
        Discoidin Domain Receptors [D12.776.543.750.630.005]
        
        ErbB Receptors [D12.776.543.750.630.009]
        
        fms-Like Tyrosine Kinase 3 [D12.776.543.750.630.020]
        
        Proto-Oncogene Proteins c-kit [D12.776.543.750.630.124]
        
        Proto-Oncogene Proteins c-met [D12.776.543.750.630.186]
        
        Proto-Oncogene Proteins c-ret [D12.776.543.750.630.217]
        
        Receptor Tyrosine Kinase-like Orphan Receptors [D12.776.543.750.630.233]
        
        Receptor, Fibroblast Growth Factor, Type 1 [D12.776.543.750.630.440]
        
        Receptor, Fibroblast Growth Factor, Type 2 [D12.776.543.750.630.441]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D12.776.543.750.630.442]
        
        Receptor, Fibroblast Growth Factor, Type 4 [D12.776.543.750.630.443]
        
        Receptor, IGF Type 1 [D12.776.543.750.630.468]
        
        Receptor, Insulin [D12.776.543.750.630.484]
        
        Receptor, Macrophage Colony-Stimulating Factor [D12.776.543.750.630.492]
        
        Receptor, trkA [D12.776.543.750.630.496]
        
        Receptor, trkB [D12.776.543.750.630.498]
        
        Receptor, trkC [D12.776.543.750.630.499]
        
        Receptors, Eph Family [D12.776.543.750.630.500]
        
        Receptors, Platelet-Derived Growth Factor [D12.776.543.750.630.625]
        
        Receptors, TIE [D12.776.543.750.630.687]
        
        Receptors, Vascular Endothelial Growth Factor [D12.776.543.750.630.750]
        
        Vascular Endothelial Growth Factor Receptor-1 [D12.776.543.750.630.750.100]
        
        Vascular Endothelial Growth Factor Receptor-2 [D12.776.543.750.630.750.200]
        
        Vascular Endothelial Growth Factor Receptor-3 [D12.776.543.750.630.750.300]
        
        Axl Receptor Tyrosine Kinase [D12.776.543.750.630.875]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Peptide [D12.776.543.750.750]
        
        Receptors, Growth Factor [D12.776.543.750.750.400]
        
        Bone Morphogenetic Protein Receptors [D12.776.543.750.750.400.049]
        
        ErbB Receptors [D12.776.543.750.750.400.074]
        
        Proto-Oncogene Proteins c-met [D12.776.543.750.750.400.100]
        
        Receptors, Colony-Stimulating Factor [D12.776.543.750.750.400.200]
        
        Receptors, Fibroblast Growth Factor [D12.776.543.750.750.400.370]
        
        Receptors, Nerve Growth Factor [D12.776.543.750.750.400.550]
        
        Receptors, Platelet-Derived Growth Factor [D12.776.543.750.750.400.630]
        
        Receptors, Somatomedin [D12.776.543.750.750.400.780]
        
        Receptors, Transforming Growth Factor beta [D12.776.543.750.750.400.820]
        
        Receptors, Vascular Endothelial Growth Factor [D12.776.543.750.750.400.910]
        
        Vascular Endothelial Growth Factor Receptor-1 [D12.776.543.750.750.400.910.100]
        
        Vascular Endothelial Growth Factor Receptor-2 [D12.776.543.750.750.400.910.200]
        
        Vascular Endothelial Growth Factor Receptor-3 [D12.776.543.750.750.400.910.300]

Receptors, Vascular Endothelial Growth Factor Preferred

Concept UI: M0185203
Scope Note: A family of closely related RECEPTOR PROTEIN-TYROSINE KINASES that bind vascular endothelial growth factors. They share a cluster of seven extracellular IG-LIKE DOMAINS which are important for ligand binding. They are highly expressed in vascular endothelial cells and are critical for the physiological and pathological growth, development and maintenance of blood and lymphatic vessels.
Terms: Receptors, Vascular Endothelial Growth Factor Preferred Term
Term UI T215206
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); Receptor, Vascular Endothelial Cell Growth Factor
Term UI T215204
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); Receptor, Vascular Permeability Factor
Term UI T215205
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); Vascular Permeability Factor Receptor
Term UI T215207
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); Vascular Endothelial Cell Growth Factor Receptor
Term UI T215208
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); VPF Receptor
Term UI T412634
Date04/25/2000
LexicalTag ACX
ThesaurusID NLM (2003); Vascular Endothelial Growth Factor Receptor
Term UI T412635
Date04/25/2000
LexicalTag NON
ThesaurusID NLM (2003); VEGF Receptor
Term UI T215200
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2003); VEGF Receptors
Term UI T491173
Date04/26/2002
LexicalTag ACX
ThesaurusID NLM (2003)

Endothelial Growth Factor Receptor Broader

Receptors, Vascular Endothelial Growth Factor MeSH Descriptor Data 2025