MeSH Browser

MeSH Heading: ErbB Receptors
Tree Number(s): D08.811.913.696.620.682.725.400.009; D12.776.476.568.400.009; D12.776.543.750.630.009; D12.776.543.750.750.400.074
Unique ID: D066246
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D066246
Scope Note: A family of structurally related cell-surface receptors that signal through an intrinsic PROTEIN-TYROSINE KINASE. The receptors are activated upon binding of specific ligands which include EPIDERMAL GROWTH FACTORS, and NEUREGULINS.
Entry Term(s): EGF Receptor; EGF Receptors; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Family Protein; Epidermal Growth Factor Receptor Family Proteins; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; ErbB Receptor; HER Family Receptor; HER Family Receptors; Proto-oncogene c-ErbB-1 Protein; Receptor Tyrosine-protein Kinase erbB-1; Receptor, EGF; Receptor, Epidermal Growth Factor; Receptor, ErbB-1; Receptor, TGF-alpha; Receptor, Transforming-Growth Factor alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor; Receptors, Epidermal Growth Factor-Urogastrone; TGF-alpha Receptor; Transforming Growth Factor alpha Receptor; Urogastrone Receptor; c-erbB-1 Protein; erbB-1 Proto-Oncogene Protein
NLM Classification #: QU 55.7
See Also: Genes, erbB
Public MeSH Note: 2019; for RECEPTOR, EPIDERMAL GROWTH FACTOR see RECEPTOR, EPIDERMAL GROWTH FACTOR 1999-2018; see RECEPTORS, EPIDERMAL GROWTH FACTOR-UROGASTRONE 1978-1999; for EPIDERMAL GROWTH FACTOR RECEPTOR PROTEIN-TYROSINE KINASE see EPIDERMAL GROWTH FACTOR RECEPTOR PROTEIN-TYROSINE KINASE 1994-1999
History Note: 2019 (2015); for RECEPTOR, EPIDERMAL GROWTH FACTOR use RECEPTOR, EPIDERMAL GROWTH FACTOR 1999-2018; for EPIDERMAL GROWTH FACTOR RECEPTOR PROTEIN-TYROSINE KINASE use RECEPTOR, EPIDERMAL GROWTH FACTOR 1994-1999
Date Established: 2015/01/01
Date of Entry: 2014/06/26
Revision Date: 2021/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
        
        Receptor Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.400]
        
        Anaplastic Lymphoma Kinase [D08.811.913.696.620.682.725.400.002]
        
        c-Mer Tyrosine Kinase [D08.811.913.696.620.682.725.400.003]
        
        Discoidin Domain Receptors [D08.811.913.696.620.682.725.400.005]
        
        ErbB Receptors [D08.811.913.696.620.682.725.400.009]
        
        Receptor, ErbB-2 [D08.811.913.696.620.682.725.400.009.400]
        
        Receptor, ErbB-3 [D08.811.913.696.620.682.725.400.009.500]
        
        Receptor, ErbB-4 [D08.811.913.696.620.682.725.400.009.600]
        
        fms-Like Tyrosine Kinase 3 [D08.811.913.696.620.682.725.400.020]
        
        Proto-Oncogene Proteins c-kit [D08.811.913.696.620.682.725.400.050]
        
        Proto-Oncogene Proteins c-met [D08.811.913.696.620.682.725.400.075]
        
        Proto-Oncogene Proteins c-ret [D08.811.913.696.620.682.725.400.087]
        
        Receptor Tyrosine Kinase-like Orphan Receptors [D08.811.913.696.620.682.725.400.093]
        
        Receptor, Fibroblast Growth Factor, Type 1 [D08.811.913.696.620.682.725.400.177]
        
        Receptor, Fibroblast Growth Factor, Type 2 [D08.811.913.696.620.682.725.400.178]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D08.811.913.696.620.682.725.400.179]
        
        Receptor, Fibroblast Growth Factor, Type 4 [D08.811.913.696.620.682.725.400.180]
        
        Receptor, IGF Type 1 [D08.811.913.696.620.682.725.400.185]
        
        Receptor, Insulin [D08.811.913.696.620.682.725.400.200]
        
        Receptor, Macrophage Colony-Stimulating Factor [D08.811.913.696.620.682.725.400.500]
        
        Receptor, trkA [D08.811.913.696.620.682.725.400.660]
        
        Receptor, trkB [D08.811.913.696.620.682.725.400.700]
        
        Receptor, trkC [D08.811.913.696.620.682.725.400.800]
        
        Receptors, Eph Family [D08.811.913.696.620.682.725.400.850]
        
        Receptors, Platelet-Derived Growth Factor [D08.811.913.696.620.682.725.400.900]
        
        Receptors, TIE [D08.811.913.696.620.682.725.400.925]
        
        Receptors, Vascular Endothelial Growth Factor [D08.811.913.696.620.682.725.400.950]
        
        Axl Receptor Tyrosine Kinase [D08.811.913.696.620.682.725.400.975]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein-Tyrosine Kinases [D12.776.476.568]
      - Receptor Protein-Tyrosine Kinases [D12.776.476.568.400]
        
        Anaplastic Lymphoma Kinase [D12.776.476.568.400.002]
        
        c-Mer Tyrosine Kinase [D12.776.476.568.400.003]
        
        Discoidin Domain Receptors [D12.776.476.568.400.005]
        
        ErbB Receptors [D12.776.476.568.400.009]
        
        Receptor, ErbB-2 [D12.776.476.568.400.009.400]
        
        Receptor, ErbB-3 [D12.776.476.568.400.009.500]
        
        Receptor, ErbB-4 [D12.776.476.568.400.009.600]
        
        fms-Like Tyrosine Kinase 3 [D12.776.476.568.400.020]
        
        Proto-Oncogene Proteins c-kit [D12.776.476.568.400.050]
        
        Proto-Oncogene Proteins c-met [D12.776.476.568.400.075]
        
        Proto-Oncogene Proteins c-ret [D12.776.476.568.400.087]
        
        Receptor Tyrosine Kinase-like Orphan Receptors [D12.776.476.568.400.093]
        
        Receptor, Fibroblast Growth Factor, Type 1 [D12.776.476.568.400.177]
        
        Receptor, Fibroblast Growth Factor, Type 2 [D12.776.476.568.400.178]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D12.776.476.568.400.179]
        
        Receptor, Fibroblast Growth Factor, Type 4 [D12.776.476.568.400.180]
        
        Receptor, IGF Type 1 [D12.776.476.568.400.185]
        
        Receptor, Insulin [D12.776.476.568.400.200]
        
        Receptor, Macrophage Colony-Stimulating Factor [D12.776.476.568.400.500]
        
        Receptor, trkA [D12.776.476.568.400.660]
        
        Receptor, trkB [D12.776.476.568.400.700]
        
        Receptor, trkC [D12.776.476.568.400.800]
        
        Receptors, Eph Family [D12.776.476.568.400.850]
        
        Receptors, Platelet-Derived Growth Factor [D12.776.476.568.400.900]
        
        Receptors, TIE [D12.776.476.568.400.925]
        
        Receptors, Vascular Endothelial Growth Factor [D12.776.476.568.400.950]
        
        Axl Receptor Tyrosine Kinase [D12.776.476.568.400.975]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptor Protein-Tyrosine Kinases [D12.776.543.750.630]
        
        Anaplastic Lymphoma Kinase [D12.776.543.750.630.002]
        
        c-Mer Tyrosine Kinase [D12.776.543.750.630.003]
        
        Discoidin Domain Receptors [D12.776.543.750.630.005]
        
        ErbB Receptors [D12.776.543.750.630.009]
        
        Receptor, ErbB-2 [D12.776.543.750.630.009.400]
        
        Receptor, ErbB-3 [D12.776.543.750.630.009.500]
        
        Receptor, ErbB-4 [D12.776.543.750.630.009.600]
        
        fms-Like Tyrosine Kinase 3 [D12.776.543.750.630.020]
        
        Proto-Oncogene Proteins c-kit [D12.776.543.750.630.124]
        
        Proto-Oncogene Proteins c-met [D12.776.543.750.630.186]
        
        Proto-Oncogene Proteins c-ret [D12.776.543.750.630.217]
        
        Receptor Tyrosine Kinase-like Orphan Receptors [D12.776.543.750.630.233]
        
        Receptor, Fibroblast Growth Factor, Type 1 [D12.776.543.750.630.440]
        
        Receptor, Fibroblast Growth Factor, Type 2 [D12.776.543.750.630.441]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D12.776.543.750.630.442]
        
        Receptor, Fibroblast Growth Factor, Type 4 [D12.776.543.750.630.443]
        
        Receptor, IGF Type 1 [D12.776.543.750.630.468]
        
        Receptor, Insulin [D12.776.543.750.630.484]
        
        Receptor, Macrophage Colony-Stimulating Factor [D12.776.543.750.630.492]
        
        Receptor, trkA [D12.776.543.750.630.496]
        
        Receptor, trkB [D12.776.543.750.630.498]
        
        Receptor, trkC [D12.776.543.750.630.499]
        
        Receptors, Eph Family [D12.776.543.750.630.500]
        
        Receptors, Platelet-Derived Growth Factor [D12.776.543.750.630.625]
        
        Receptors, TIE [D12.776.543.750.630.687]
        
        Receptors, Vascular Endothelial Growth Factor [D12.776.543.750.630.750]
        
        Axl Receptor Tyrosine Kinase [D12.776.543.750.630.875]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Peptide [D12.776.543.750.750]
        
        Receptors, Growth Factor [D12.776.543.750.750.400]
        
        Bone Morphogenetic Protein Receptors [D12.776.543.750.750.400.049]
        
        ErbB Receptors [D12.776.543.750.750.400.074]
        
        Receptor, ErbB-2 [D12.776.543.750.750.400.074.400]
        
        Receptor, ErbB-3 [D12.776.543.750.750.400.074.500]
        
        Receptor, ErbB-4 [D12.776.543.750.750.400.074.600]
        
        Proto-Oncogene Proteins c-met [D12.776.543.750.750.400.100]
        
        Receptors, Colony-Stimulating Factor [D12.776.543.750.750.400.200]
        
        Receptors, Fibroblast Growth Factor [D12.776.543.750.750.400.370]
        
        Receptors, Nerve Growth Factor [D12.776.543.750.750.400.550]
        
        Receptors, Platelet-Derived Growth Factor [D12.776.543.750.750.400.630]
        
        Receptors, Somatomedin [D12.776.543.750.750.400.780]
        
        Receptors, Transforming Growth Factor beta [D12.776.543.750.750.400.820]
        
        Receptors, Vascular Endothelial Growth Factor [D12.776.543.750.750.400.910]

ErbB Receptors Preferred

HER Family Receptors Narrower

EGF Receptors Narrower

Receptor, ErbB-1 Narrower

Concept UI: M000640867
Terms: Receptor, ErbB-1 Preferred Term
Term UI T859483
Date05/09/2014
LexicalTag ACX
ThesaurusID NLM (2015); Receptor Tyrosine-protein Kinase erbB-1
Term UI T000928674
Date07/14/2017
LexicalTag NON
ThesaurusID NLM (2018); Proto-oncogene c-ErbB-1 Protein
Term UI T859484
Date05/09/2014
LexicalTag NON
ThesaurusID NLM (2015); erbB-1 Proto-Oncogene Protein
Term UI T361904
Date11/04/1999
LexicalTag NON
ThesaurusID NLM (2000); c-erbB-1 Protein
Term UI T449833
Date06/08/2001
LexicalTag ABX
ThesaurusID NLM (2002)

ErbB Receptors MeSH Descriptor Data 2025