MeSH Browser

MeSH Heading: Receptor, ErbB-3
Tree Number(s): D08.811.913.696.620.682.725.400.009.500; D12.776.476.568.400.009.500; D12.776.543.750.630.009.500; D12.776.543.750.750.400.074.500; D12.776.624.664.700.790; D23.101.140.721
Unique ID: D020893
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D020893
Scope Note: A cell surface protein-tyrosine kinase receptor that is specific for NEUREGULINS. It has extensive homology to and can heterodimerize with the EGF RECEPTOR and the ERBB-2 RECEPTOR. Overexpression of the erbB-3 receptor is associated with TUMORIGENESIS.
Entry Term(s): HER-3 Proto-Oncogene Protein; Proto-Oncogene Protein c-erbB-3; Proto-Oncogene Protein erbB-3; Proto-Oncogene Proteins erbB-3; Proto-oncogene-like Protein c-ErbB-2; Tyrosine Kinase-type Cell Surface Receptor HER3; c-erbB-3 Protein; erbB-3 Protein
Previous Indexing: Proto-Oncogene Proteins (1993-1999); Receptor, Epidermal Growth Factor (1990-1999)
See Also: Arthrogryposis; Genes, erbB
Public MeSH Note: 2000; PROTO-ONCOGENE PROTEIN ERBB-3 (now RECEPTOR, ERBB-3) was indexed under EPIDERMAL GROWTH FACTOR RECEPTOR PROTEIN-TYROSINE KINASE 1993-1999 & PROTO-ONCOGENE PROTEINS 1990-1999
History Note: 2000; use RECEPTOR, ERBB-3 (NM) 1990-1999
Date Established: 2000/01/01
Date of Entry: 1999/11/03
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
        
        Receptor Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.400]
        
        ErbB Receptors [D08.811.913.696.620.682.725.400.009]
        
        Receptor, ErbB-2 [D08.811.913.696.620.682.725.400.009.400]
        
        Receptor, ErbB-3 [D08.811.913.696.620.682.725.400.009.500]
        
        Receptor, ErbB-4 [D08.811.913.696.620.682.725.400.009.600]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein-Tyrosine Kinases [D12.776.476.568]
      - Receptor Protein-Tyrosine Kinases [D12.776.476.568.400]
        
        ErbB Receptors [D12.776.476.568.400.009]
        
        Receptor, ErbB-2 [D12.776.476.568.400.009.400]
        
        Receptor, ErbB-3 [D12.776.476.568.400.009.500]
        
        Receptor, ErbB-4 [D12.776.476.568.400.009.600]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptor Protein-Tyrosine Kinases [D12.776.543.750.630]
        
        ErbB Receptors [D12.776.543.750.630.009]
        
        Receptor, ErbB-2 [D12.776.543.750.630.009.400]
        
        Receptor, ErbB-3 [D12.776.543.750.630.009.500]
        
        Receptor, ErbB-4 [D12.776.543.750.630.009.600]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Peptide [D12.776.543.750.750]
        
        Receptors, Growth Factor [D12.776.543.750.750.400]
        
        ErbB Receptors [D12.776.543.750.750.400.074]
        
        Receptor, ErbB-2 [D12.776.543.750.750.400.074.400]
        
        Receptor, ErbB-3 [D12.776.543.750.750.400.074.500]
        
        Receptor, ErbB-4 [D12.776.543.750.750.400.074.600]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Neoplasm Proteins [D12.776.624]
    - Oncogene Proteins [D12.776.624.664]
      - Proto-Oncogene Proteins [D12.776.624.664.700]
        
        Axl Receptor Tyrosine Kinase [D12.776.624.664.700.013]
        
        Bcl-2-Like Protein 11 [D12.776.624.664.700.025]
        
        c-Mer Tyrosine Kinase [D12.776.624.664.700.037]
        
        Chemokine CXCL1 [D12.776.624.664.700.049]
        
        Cyclin D1 [D12.776.624.664.700.100]
        
        Fibroblast Growth Factor 4 [D12.776.624.664.700.110]
        
        Fibroblast Growth Factor 6 [D12.776.624.664.700.112]
        
        fms-Like Tyrosine Kinase 3 [D12.776.624.664.700.114]
        
        Janus Kinase 2 [D12.776.624.664.700.117]
        
        KRIT1 Protein [D12.776.624.664.700.119]
        
        Kruppel-Like Factor 6 [D12.776.624.664.700.120]
        
        Lipocalin-2 [D12.776.624.664.700.123]
        
        Lymphocyte Specific Protein Tyrosine Kinase p56(lck) [D12.776.624.664.700.128]
        
        MDS1 and EVI1 Complex Locus Protein [D12.776.624.664.700.129]
        
        MutS Homolog 2 Protein [D12.776.624.664.700.130]
        
        Myeloid-Lymphoid Leukemia Protein [D12.776.624.664.700.148]
        
        N-Myc Proto-Oncogene Protein [D12.776.624.664.700.158]
        
        Pre-B-Cell Leukemia Transcription Factor 1 [D12.776.624.664.700.163]
        
        B-Cell Lymphoma 3 Protein [D12.776.624.664.700.165]
        
        Proto-Oncogene Mas [D12.776.624.664.700.166]
        
        Proto-Oncogene Proteins c-abl [D12.776.624.664.700.167]
        
        Proto-Oncogene Proteins c-akt [D12.776.624.664.700.168]
        
        Proto-Oncogene Proteins c-bcl-2 [D12.776.624.664.700.169]
        
        Proto-Oncogene Proteins c-bcl-6 [D12.776.624.664.700.170]
        
        Proto-Oncogene Proteins c-bcr [D12.776.624.664.700.171]
        
        Proto-Oncogene Proteins c-cbl [D12.776.624.664.700.172]
        
        Proto-Oncogene Proteins c-crk [D12.776.624.664.700.174]
        
        Proto-Oncogene Proteins c-ets [D12.776.624.664.700.175]
        
        Proto-Oncogene Proteins c-fes [D12.776.624.664.700.177]
        
        Proto-Oncogene Proteins c-fos [D12.776.624.664.700.179]
        
        Proto-Oncogene Proteins c-fyn [D12.776.624.664.700.180]
        
        Proto-Oncogene Proteins c-hck [D12.776.624.664.700.181]
        
        Proto-Oncogene Proteins c-jun [D12.776.624.664.700.182]
        
        Proto-Oncogene Proteins c-kit [D12.776.624.664.700.183]
        
        Proto-Oncogene Proteins c-maf [D12.776.624.664.700.184]
        
        Proto-Oncogene Proteins c-mdm2 [D12.776.624.664.700.185]
        
        Proto-Oncogene Proteins c-met [D12.776.624.664.700.186]
        
        Proto-Oncogene Proteins c-mos [D12.776.624.664.700.187]
        
        Proto-Oncogene Proteins c-myb [D12.776.624.664.700.188]
        
        Proto-Oncogene Proteins c-myc [D12.776.624.664.700.189]
        
        Proto-Oncogene Proteins c-pim-1 [D12.776.624.664.700.191]
        
        Proto-Oncogene Proteins c-rel [D12.776.624.664.700.192]
        
        Proto-Oncogene Proteins c-ret [D12.776.624.664.700.194]
        
        Proto-Oncogene Proteins c-sis [D12.776.624.664.700.195]
        
        Proto-Oncogene Proteins c-vav [D12.776.624.664.700.198]
        
        Proto-Oncogene Proteins c-yes [D12.776.624.664.700.199]
        
        Proto-Oncogene Proteins p21(ras) [D12.776.624.664.700.200]
        
        Proto-Oncogene Proteins pp60(c-src) [D12.776.624.664.700.202]
        
        raf Kinases [D12.776.624.664.700.204]
        
        Receptor, ErbB-2 [D12.776.624.664.700.642]
        
        Receptor, ErbB-3 [D12.776.624.664.700.790]
        
        Receptor, ErbB-4 [D12.776.624.664.700.791]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D12.776.624.664.700.792]
        
        Receptor, Macrophage Colony-Stimulating Factor [D12.776.624.664.700.800]
        
        Receptor, Notch4 [D12.776.624.664.700.815]
        
        Receptors, Thyroid Hormone [D12.776.624.664.700.830]
        
        RNA-Binding Protein EWS [D12.776.624.664.700.913]
        
        RNA-Binding Protein FUS [D12.776.624.664.700.915]
        
        RUNX1 Translocation Partner 1 Protein [D12.776.624.664.700.936]
        
        Stathmin [D12.776.624.664.700.957]
        
        T-Cell Acute Lymphocytic Leukemia Protein 1 [D12.776.624.664.700.960]
        
        Wnt-5a Protein [D12.776.624.664.700.962]
        
        Wnt1 Protein [D12.776.624.664.700.967]
        
        Wnt2 Protein [D12.776.624.664.700.978]
        
        Zinc Finger Protein GLI1 [D12.776.624.664.700.989]

Biological Factors [D23]
- Biomarkers [D23.101]
  - Biomarkers, Tumor [D23.101.140]

Receptor, ErbB-3 Preferred

Concept UI: M0328262
Scope Note: A cell surface protein-tyrosine kinase receptor that is specific for NEUREGULINS. It has extensive homology to and can heterodimerize with the EGF RECEPTOR and the ERBB-2 RECEPTOR. Overexpression of the erbB-3 receptor is associated with TUMORIGENESIS.
Terms: Receptor, ErbB-3 Preferred Term
Term UI T858230
Date04/10/2014
LexicalTag ABX
ThesaurusID NLM (2015); Proto-Oncogene Protein erbB-3
Term UI T201816
Date10/12/1999
LexicalTag ABX
ThesaurusID NLM (2000); erbB-3 Protein
Term UI T363087
Date10/12/1999
LexicalTag ABX
ThesaurusID NLM (2000); HER-3 Proto-Oncogene Protein
Term UI T363096
Date10/12/1999
LexicalTag ABX
ThesaurusID NLM (2000); Proto-Oncogene Protein c-erbB-3
Term UI T363097
Date10/12/1999
LexicalTag ABX
ThesaurusID NLM (2000); Proto-Oncogene Proteins erbB-3
Term UI T363100
Date10/12/1999
LexicalTag ABX
ThesaurusID NLM (2000); Proto-oncogene-like Protein c-ErbB-2
Term UI T859497
Date05/09/2014
LexicalTag ABX
ThesaurusID NLM (2015); c-erbB-3 Protein
Term UI T201811
Date10/12/1999
LexicalTag ABX
ThesaurusID NLM (2000); Tyrosine Kinase-type Cell Surface Receptor HER3
Term UI T859499
Date05/09/2014
LexicalTag NON
ThesaurusID NLM (2015)

Receptor, ErbB-3 MeSH Descriptor Data 2025