MeSH Browser

MeSH Heading: Proto-Oncogene Proteins p21(ras)
Tree Number(s): D08.811.277.040.330.300.400.500.600; D12.776.157.325.515.500.600; D12.776.476.338.400.500.600; D12.776.624.664.700.200
Unique ID: D016283
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016283
Scope Note: Cellular proteins encoded by the H-ras, K-ras and N-ras genes. The proteins have GTPase activity and are involved in signal transduction as monomeric GTP-binding proteins. Elevated levels of p21 c-ras have been associated with neoplasia. This enzyme was formerly listed as EC 3.6.1.47.
Entry Term(s): Proto-Oncogene Protein p21(c-Ha-ras); Proto-Oncogene Protein p21(c-Ki-ras); Proto-Oncogene Protein p21(c-N-ras); Proto-Oncogene Protein p21(ras); Proto-Oncogene Protein ras; Proto-Oncogene Proteins c-ras; c-Ha-ras p21; c-Ki-ras p21; c-ras Proteins; p21 c-H-ras; p21 c-Ha-ras; p21 c-K-ras; p21 c-Ki-ras; p21 c-ras; p21(N-ras); p21(c-Ha-ras); p21(c-Ki-ras); p21(c-ras); p21(ras); ras Proto-Oncogene Product p21; ras Proto-Oncogene Protein p21
Registry Numbers: EC 3.6.5.2; EC 2.6.1.-; EC 3.6.1.-; EC 3.6.1.-
Previous Indexing: Neoplasm Proteins (1983-1986); Proto-Oncogene Proteins (1987-1990)
See Also: Costello Syndrome
Public MeSH Note: 2006; for P21(RAS) see ONCOGENE PROTEIN P21(RAS) 1990
History Note: 2006(1991)
Date Established: 1991/01/01
Date of Entry: 1990/06/19
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Acid Anhydride Hydrolases [D08.811.277.040]
      - GTP Phosphohydrolases [D08.811.277.040.330]
        
        GTP-Binding Proteins [D08.811.277.040.330.300]
        
        Monomeric GTP-Binding Proteins [D08.811.277.040.330.300.400]
        
        ras Proteins [D08.811.277.040.330.300.400.500]
        
        Oncogene Protein p21(ras) [D08.811.277.040.330.300.400.500.300]
        
        Proto-Oncogene Proteins p21(ras) [D08.811.277.040.330.300.400.500.600]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - GTP-Binding Proteins [D12.776.157.325]
      - Monomeric GTP-Binding Proteins [D12.776.157.325.515]
        
        ras Proteins [D12.776.157.325.515.500]
        
        Oncogene Protein p21(ras) [D12.776.157.325.515.500.300]
        
        Proto-Oncogene Proteins p21(ras) [D12.776.157.325.515.500.600]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - GTP-Binding Proteins [D12.776.476.338]
      - Monomeric GTP-Binding Proteins [D12.776.476.338.400]
        
        ras Proteins [D12.776.476.338.400.500]
        
        Oncogene Protein p21(ras) [D12.776.476.338.400.500.300]
        
        Proto-Oncogene Proteins p21(ras) [D12.776.476.338.400.500.600]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Neoplasm Proteins [D12.776.624]
    - Oncogene Proteins [D12.776.624.664]
      - Proto-Oncogene Proteins [D12.776.624.664.700]
        
        Axl Receptor Tyrosine Kinase [D12.776.624.664.700.013]
        
        Bcl-2-Like Protein 11 [D12.776.624.664.700.025]
        
        c-Mer Tyrosine Kinase [D12.776.624.664.700.037]
        
        Chemokine CXCL1 [D12.776.624.664.700.049]
        
        Cyclin D1 [D12.776.624.664.700.100]
        
        Fibroblast Growth Factor 4 [D12.776.624.664.700.110]
        
        Fibroblast Growth Factor 6 [D12.776.624.664.700.112]
        
        fms-Like Tyrosine Kinase 3 [D12.776.624.664.700.114]
        
        Janus Kinase 2 [D12.776.624.664.700.117]
        
        KRIT1 Protein [D12.776.624.664.700.119]
        
        Kruppel-Like Factor 6 [D12.776.624.664.700.120]
        
        Lipocalin-2 [D12.776.624.664.700.123]
        
        Lymphocyte Specific Protein Tyrosine Kinase p56(lck) [D12.776.624.664.700.128]
        
        MDS1 and EVI1 Complex Locus Protein [D12.776.624.664.700.129]
        
        MutS Homolog 2 Protein [D12.776.624.664.700.130]
        
        Myeloid-Lymphoid Leukemia Protein [D12.776.624.664.700.148]
        
        N-Myc Proto-Oncogene Protein [D12.776.624.664.700.158]
        
        Pre-B-Cell Leukemia Transcription Factor 1 [D12.776.624.664.700.163]
        
        B-Cell Lymphoma 3 Protein [D12.776.624.664.700.165]
        
        Proto-Oncogene Mas [D12.776.624.664.700.166]
        
        Proto-Oncogene Proteins c-abl [D12.776.624.664.700.167]
        
        Proto-Oncogene Proteins c-akt [D12.776.624.664.700.168]
        
        Proto-Oncogene Proteins c-bcl-2 [D12.776.624.664.700.169]
        
        Proto-Oncogene Proteins c-bcl-6 [D12.776.624.664.700.170]
        
        Proto-Oncogene Proteins c-bcr [D12.776.624.664.700.171]
        
        Proto-Oncogene Proteins c-cbl [D12.776.624.664.700.172]
        
        Proto-Oncogene Proteins c-crk [D12.776.624.664.700.174]
        
        Proto-Oncogene Proteins c-ets [D12.776.624.664.700.175]
        
        Proto-Oncogene Proteins c-fes [D12.776.624.664.700.177]
        
        Proto-Oncogene Proteins c-fos [D12.776.624.664.700.179]
        
        Proto-Oncogene Proteins c-fyn [D12.776.624.664.700.180]
        
        Proto-Oncogene Proteins c-hck [D12.776.624.664.700.181]
        
        Proto-Oncogene Proteins c-jun [D12.776.624.664.700.182]
        
        Proto-Oncogene Proteins c-kit [D12.776.624.664.700.183]
        
        Proto-Oncogene Proteins c-maf [D12.776.624.664.700.184]
        
        Proto-Oncogene Proteins c-mdm2 [D12.776.624.664.700.185]
        
        Proto-Oncogene Proteins c-met [D12.776.624.664.700.186]
        
        Proto-Oncogene Proteins c-mos [D12.776.624.664.700.187]
        
        Proto-Oncogene Proteins c-myb [D12.776.624.664.700.188]
        
        Proto-Oncogene Proteins c-myc [D12.776.624.664.700.189]
        
        Proto-Oncogene Proteins c-pim-1 [D12.776.624.664.700.191]
        
        Proto-Oncogene Proteins c-rel [D12.776.624.664.700.192]
        
        Proto-Oncogene Proteins c-ret [D12.776.624.664.700.194]
        
        Proto-Oncogene Proteins c-sis [D12.776.624.664.700.195]
        
        Proto-Oncogene Proteins c-vav [D12.776.624.664.700.198]
        
        Proto-Oncogene Proteins c-yes [D12.776.624.664.700.199]
        
        Proto-Oncogene Proteins p21(ras) [D12.776.624.664.700.200]
        
        Proto-Oncogene Proteins pp60(c-src) [D12.776.624.664.700.202]
        
        raf Kinases [D12.776.624.664.700.204]
        
        Receptor, ErbB-2 [D12.776.624.664.700.642]
        
        Receptor, ErbB-3 [D12.776.624.664.700.790]
        
        Receptor, ErbB-4 [D12.776.624.664.700.791]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D12.776.624.664.700.792]
        
        Receptor, Macrophage Colony-Stimulating Factor [D12.776.624.664.700.800]
        
        Receptor, Notch4 [D12.776.624.664.700.815]
        
        Receptors, Thyroid Hormone [D12.776.624.664.700.830]
        
        RNA-Binding Protein EWS [D12.776.624.664.700.913]
        
        RNA-Binding Protein FUS [D12.776.624.664.700.915]
        
        RUNX1 Translocation Partner 1 Protein [D12.776.624.664.700.936]
        
        Stathmin [D12.776.624.664.700.957]
        
        T-Cell Acute Lymphocytic Leukemia Protein 1 [D12.776.624.664.700.960]
        
        Wnt-5a Protein [D12.776.624.664.700.962]
        
        Wnt1 Protein [D12.776.624.664.700.967]
        
        Wnt2 Protein [D12.776.624.664.700.978]
        
        Zinc Finger Protein GLI1 [D12.776.624.664.700.989]

Proto-Oncogene Proteins p21(ras) Preferred

Concept UI: M0024891
Registry Numbers: EC 3.6.5.2
Scope Note: Cellular proteins encoded by the H-ras, K-ras and N-ras genes. The proteins have GTPase activity and are involved in signal transduction as monomeric GTP-binding proteins. Elevated levels of p21 c-ras have been associated with neoplasia. This enzyme was formerly listed as EC 3.6.1.47.
Terms: Proto-Oncogene Proteins p21(ras) Preferred Term
Term UI T631852
Date02/28/2005
LexicalTag ACX
ThesaurusID NLM (2006); p21 c-ras
Term UI T048546
Date04/04/1990
LexicalTag NON
ThesaurusID NLM (1991); p21(c-ras)
Term UI T048547
Date04/04/1990
LexicalTag NON
ThesaurusID NLM (1991); ras Proto-Oncogene Protein p21
Term UI T048548
Date04/04/1990
LexicalTag NON
ThesaurusID NLM (1991); Proto-Oncogene Protein p21(ras)
Term UI T048549
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1991); Proto-Oncogene Protein ras
Term UI T048550
Date05/02/1990
LexicalTag NON
ThesaurusID NLM (1991); ras Proto-Oncogene Product p21
Term UI T048551
Date04/04/1990
LexicalTag NON
ThesaurusID NLM (1991); c-ras Proteins
Term UI T632438
Date03/04/2005
LexicalTag ABX
ThesaurusID NLM (2006); p21(ras)
Term UI T048545
Date04/04/1990
LexicalTag NON
ThesaurusID NLM (1991); Proto-Oncogene Proteins c-ras
Term UI T632439
Date03/04/2005
LexicalTag NON
ThesaurusID NLM (2006)

Proto-Oncogene Protein p21(c-Ha-ras) Narrower

Concept UI: M0024888
Registry Numbers: EC 2.6.1.-
Terms: Proto-Oncogene Protein p21(c-Ha-ras) Preferred Term
Term UI T632440
Date03/04/2005
LexicalTag NON
ThesaurusID NLM (2006); p21 c-Ha-ras
Term UI T048538
Date04/04/1990
LexicalTag NON
ThesaurusID NLM (1991); c-Ha-ras p21
Term UI T048539
Date04/04/1990
LexicalTag NON
ThesaurusID NLM (1991); p21(c-Ha-ras)
Term UI T048540
Date04/04/1990
LexicalTag NON
ThesaurusID NLM (1991); p21 c-H-ras
Term UI T048536
Date04/04/1990
LexicalTag NON
ThesaurusID NLM (1991)

Proto-Oncogene Protein p21(c-Ki-ras) Narrower

Concept UI: M0024889
Registry Numbers: EC 3.6.1.-
Terms: Proto-Oncogene Protein p21(c-Ki-ras) Preferred Term
Term UI T632441
Date03/04/2005
LexicalTag NON
ThesaurusID NLM (2006); p21 c-Ki-ras
Term UI T048541
Date04/04/1990
LexicalTag NON
ThesaurusID NLM (1991); c-Ki-ras p21
Term UI T048542
Date04/04/1990
LexicalTag NON
ThesaurusID NLM (1991); p21(c-Ki-ras)
Term UI T048543
Date04/04/1990
LexicalTag NON
ThesaurusID NLM (1991); p21 c-K-ras
Term UI T048537
Date04/04/1990
LexicalTag NON
ThesaurusID NLM (1991)

Proto-Oncogene Protein p21(c-N-ras) Narrower

Proto-Oncogene Proteins p21(ras) MeSH Descriptor Data 2025