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Receptor, ErbB-2 MeSH Descriptor Data 2023


MeSH Heading
Receptor, ErbB-2
Tree Number(s)
D08.811.913.696.620.682.725.400.009.400
D12.776.476.568.400.009.400
D12.776.543.750.630.009.400
D12.776.543.750.750.400.074.400
D12.776.624.664.700.642
D23.050.301.500.600.700
D23.050.705.552.600.550
D23.101.140.642
Unique ID
D018719
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D018719
Scope Note
A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.
Entry Term(s)
Antigens, CD340
CD340 Antigen
Erb-b2 Receptor Tyrosine Kinases
HER-2 Proto-Oncogene Protein
Metastatic Lymph Node Gene 19 Protein
Neu Receptor
Oncogene Protein HER-2
Proto-Oncogene Protein HER-2
Proto-Oncogene Protein p185(neu)
Proto-Oncogene Proteins c-erbB-2
Proto-oncogene Protein Neu
Receptor, Neu
Receptors, erbB-2
Tyrosine Kinase-type Cell Surface Receptor HER2
c-erbB-2 Protein
erbB-2 Proto-Oncogene Protein
erbB-2 Receptor Protein-Tyrosine Kinase
neu Proto-Oncogene Protein
p185(c-neu)
p185erbB2 Protein
Registry Number
EC 2.7.10.1
Previous Indexing
Epidermal Growth Factor Receptor Protein-Tyrosine Kinase (1994)
Phosphoproteins (1985)
Proto-Oncogene Proteins (1986-1994)
See Also
Genes, erbB-2
Trastuzumab
Public MeSH Note
2019; for ERB-B2 RECEPTOR TYROSINE KINASES see ERBB RECEPTORS 2017-2019; see PROTO-ONCOGENE PROTEINS C-ERBB-2 1995-1999; for PROTO-ONCOGENE PROTEIN ERBB-2 see EPIDERMAL GROWTH FACTOR RECEPTOR PROTEIN-TYROSINE KINASE 1994, PROTO-ONCOGENE PROTEINS 1986-1994, and PHOSPHOPROTEINS 1985;
History Note
2019 (1995)
Date Established
1995/01/01
Date of Entry
1999/11/04
Revision Date
2021/06/21
Receptor, ErbB-2 Preferred
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