MeSH Browser

MeSH Heading: Genes, erbB-2
Tree Number(s): G05.360.340.024.340.375.500.791.295.305
Unique ID: D018734
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D018734
Annotation: in titles & translations spell as erbB-2; GENES, ERBB-1 is also available
Scope Note: The erbB-2 gene is a proto-oncogene that codes for the erbB-2 receptor (RECEPTOR, ERBB-2), a protein with structural features similar to the epidermal growth factor receptor. Its name originates from the viral oncogene homolog (v-erbB) which is a truncated form of the chicken erbB gene found in the avian erythroblastosis virus. Overexpression and amplification of the gene is associated with a significant number of adenocarcinomas. The human c-erbB-2 gene is located at 17q21.2.
Entry Term(s): Genes, HER-2; Genes, HER2; Genes, erbb2; Genes, neu; c-erbB-2 Genes; c-erbB-2 Proto-Oncogenes; erbB-2 Genes
Previous Indexing: Oncogenes (1986-1994); Proto-Oncogenes (1986-1994)
See Also: ErbB Receptors; Oncogene Proteins v-erbB; Receptor, ErbB-2
Public MeSH Note: 1995
History Note: 1995
Date Established: 1995/01/01
Date of Entry: 1994/05/23
Revision Date: 2018/06/12

Allowable Qualifiers: drug effects (DE)

ethics (ES)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Concept UI: M0028066
Scope Note: The erbB-2 gene is a proto-oncogene that codes for the erbB-2 receptor (RECEPTOR, ERBB-2), a protein with structural features similar to the epidermal growth factor receptor. Its name originates from the viral oncogene homolog (v-erbB) which is a truncated form of the chicken erbB gene found in the avian erythroblastosis virus. Overexpression and amplification of the gene is associated with a significant number of adenocarcinomas. The human c-erbB-2 gene is located at 17q21.2.
Terms: Genes, erbB-2 Preferred Term
Term UI T055795
Date01/01/1999
LexicalTag ABX
ThesaurusID NLM (1995); c-erbB-2 Genes
Term UI T055796
Date04/04/1994
LexicalTag NON
ThesaurusID NLM (1995); c-erbB-2 Proto-Oncogenes
Term UI T055797
Date04/04/1994
LexicalTag NON
ThesaurusID NLM (1995); Genes, HER-2
Term UI T055798
Date02/09/1994
LexicalTag NON
ThesaurusID NLM (1995); Genes, neu
Term UI T055799
Date02/09/1994
LexicalTag NON
ThesaurusID NLM (1995); Genes, HER2
Term UI T362166
Date11/08/1999
LexicalTag NON
ThesaurusID NLM (2000); erbB-2 Genes
Term UI T055794
Date04/11/1994
LexicalTag NON
ThesaurusID NLM (1995); Genes, erbb2
Term UI T373111
Date11/08/1999
LexicalTag NON
ThesaurusID NLM (2000)

Genes, erbB-2 MeSH Descriptor Data 2025