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Proto-Oncogene Proteins c-bcr MeSH Descriptor Data 2023


MeSH Heading
Proto-Oncogene Proteins c-bcr
Tree Number(s)
D08.811.913.696.620.682.700.759
D12.644.360.325.300.099.500
D12.776.476.325.300.099.500
D12.776.476.563.759
D12.776.624.664.700.171
Unique ID
D051562
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D051562
Scope Note
A serine-threonine kinase that contains a C2 DOMAIN and PLECKSTRIN HOMOLOGY DOMAIN. It also has activity as a GTPASE-ACTIVATING PROTEIN for RAC1 PROTEIN and CDC42 PROTEIN. It functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION and is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.
Entry Term(s)
Breakpoint Cluster Region Protein
Proto-Oncogene Protein bcr
Proto-Oncogene Protein c-bcr
bcr Proto-Oncogene Proteins
c-bcr Proteins
c-bcr Proto-Oncogene Proteins
Registry Number
EC 2.7.11.1
Public MeSH Note
2006; PROTO-ONCOGENE PROTEIN C-BCR was indexed under PROTEIN-TYROSINE KINASE & PROTO-ONCOGENE PROTEINS 1988-2005
History Note
2006(1988)
Date Established
2006/01/01
Date of Entry
2005/06/30
Revision Date
2021/05/21
Proto-Oncogene Proteins c-bcr Preferred
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