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eIF-2 Kinase MeSH Descriptor Data 2023


MeSH Heading
eIF-2 Kinase
Tree Number(s)
D08.811.913.696.620.682.700.300
D12.776.476.563.300
Unique ID
D019892
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D019892
Scope Note
A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.
Entry Term(s)
DAI Protein Kinase
DSRNA-Dep Protein Kinase
Double Stranded RNA-Dependent Kinase (dsl)
Double Stranded RNA-Dependent eIF-2 alpha Protein Kinase
Eukaryotic Initiation Factor 2alpha Kinase
Heme Controlled Repressor
Heme-Controlled Inhibitor
Heme-Controlled Translational Repressor
Heme-Regulated eIF-2alpha Kinase
Hemin Controlled Repressor
Hemin-Controlled Translational Repressor
P68 Protein Kinase
Protein Kinase PKR
Protein Kinase, RNA Activated
RNA-Dependent Protein Kinase
Self-Phosphorylating Protein Kinase
TIK Kinase
dsRNA-Activated Inhibitor
eIF-2alpha Kinase
eRF, eIF-2 Recycling Factor
p65 Kinase
p68 Kinase
Registry Number
EC 2.7.11.1
Previous Indexing
Protein Kinases (1980-1993)
Protein-Serine-Threonine Kinases (1993-1997)
Public MeSH Note
98; EIF-2 KINASE was indexed under PROTEIN-SERINE-THREONINE KINASES 1993-97 & PROTEIN KINASES 1980-93
History Note
98; use EIF-2 KINASE (NM) 1980-97
Date Established
1998/01/01
Date of Entry
1997/07/02
Revision Date
2021/05/21
eIF-2 Kinase Preferred
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