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Activin Receptors MeSH Descriptor Data 2023


MeSH Heading
Activin Receptors
Tree Number(s)
D08.811.913.696.620.682.700.062
D12.776.476.563.062
D12.776.543.750.750.400.820.500
Unique ID
D029404
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D029404
Scope Note
Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE KINASES, thus also named activin receptor-like kinases (ALK's). Activin receptors also bind TRANSFORMING GROWTH FACTOR BETA. As those transmembrane receptors of the TGF-beta superfamily (RECEPTORS, TRANSFORMING GROWTH FACTOR BETA), ALK's consist of two different but related protein kinases, Type I and Type II. Activins initiate cellular signal transduction by first binding to the type II receptors (ACTIVIN RECEPTORS, TYPE II ) which then recruit and phosphorylate the type I receptors (ACTIVIN RECEPTORS, TYPE I ) with subsequent activation of the type I kinase activity.
Entry Version
ACTIVIN RECEPT
Entry Term(s)
Activin Receptor
Activin Receptor-Like Kinases
Activin Receptor-like Kinase
Receptor, Activin
Registry Number
EC 2.7.11.30
Previous Indexing
Protein-Serine-Threonine Kinases (1993-2001)
Receptors, Cell Surface (1989-1992)
Public MeSH Note
2002; ACTIVIN RECEPTORS was indexed under RECEPTORS, GROWTH FACTOR 1991-2002
History Note
2002(1991)
Date Established
2002/01/01
Date of Entry
2001/07/25
Revision Date
2021/04/21
Activin Receptors Preferred
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