MeSH Browser

MeSH Heading: MAP-Kinase-Activated Kinase 2
Tree Number(s): D08.811.913.696.620.682.700.550; D12.776.476.563.550
Unique ID: D000099190
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000099190
Scope Note: A serine-threonine protein kinase that functions in many different processes including the cellular response to PHYSIOLOGICAL STRESS, production of CYTOKINES; ENDOCYTOSIS; CYTOSKELETON dynamics, CELL MIGRATION; and CELL PROLIFERATION. It is phosphorylated by MAPK14 in response to stress, and in turn phosphorylates substrates at a SERINE that is preceded by a large hydrophobic amino acid.
Entry Term(s): HSP 27 Kinase; HSP25 Kinase; Heat Shock Protein 27 Kinase; Heat-Shock Protein 27 Kinase; MAP-Kinase-Activated Protein Kinase 2; MAPK Activated Protein Kinase 2; MAPKAP Kinase 2; MAPKAP Kinase-2; MAPKAPK-2; MAPKAPK2
Registry Numbers: EC 2.7.1.-
Public MeSH Note: 2026; MAP-KINASE-ACTIVATED KINASE 2 was indexed under PROTEIN SERINE-THREONINE KINASES and INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS 1993-2025
History Note: 2026 (1993)
Date Introduced: 2026/01/01
Last Updated: 2026/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700]
        
        Activin Receptors [D08.811.913.696.620.682.700.062]
        
        AMP-Activated Protein Kinase Kinases [D08.811.913.696.620.682.700.074]
        
        AMP-Activated Protein Kinases [D08.811.913.696.620.682.700.085]
        
        Ataxia Telangiectasia Mutated Proteins [D08.811.913.696.620.682.700.097]
        
        Aurora Kinases [D08.811.913.696.620.682.700.103]
        
        Autophagy-Related Protein-1 Homolog [D08.811.913.696.620.682.700.108]
        
        Bone Morphogenetic Protein Receptors [D08.811.913.696.620.682.700.109]
        
        Calcium-Calmodulin-Dependent Protein Kinases [D08.811.913.696.620.682.700.125]
        
        Casein Kinases [D08.811.913.696.620.682.700.140]
        
        Checkpoint Kinase 1 [D08.811.913.696.620.682.700.143]
        
        Checkpoint Kinase 2 [D08.811.913.696.620.682.700.145]
        
        Cyclic Nucleotide-Regulated Protein Kinases [D08.811.913.696.620.682.700.150]
        
        DNA-Activated Protein Kinase [D08.811.913.696.620.682.700.250]
        
        Doublecortin-Like Kinases [D08.811.913.696.620.682.700.275]
        
        Dyrk Kinases [D08.811.913.696.620.682.700.288]
        
        Hippo Kinases [D08.811.913.696.620.682.700.294]
        
        eIF-2 Kinase [D08.811.913.696.620.682.700.300]
        
        G-Protein-Coupled Receptor Kinases [D08.811.913.696.620.682.700.364]
        
        Germinal Center Kinases [D08.811.913.696.620.682.700.397]
        
        Glycogen Synthase Kinases [D08.811.913.696.620.682.700.429]
        
        I-kappa B Kinase [D08.811.913.696.620.682.700.494]
        
        Interleukin-1 Receptor-Associated Kinases [D08.811.913.696.620.682.700.526]
        
        Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 [D08.811.913.696.620.682.700.534]
        
        Lim Kinases [D08.811.913.696.620.682.700.542]
        
        MAP-Kinase-Activated Kinase 2 [D08.811.913.696.620.682.700.550]
        
        MAP Kinase Kinase Kinases [D08.811.913.696.620.682.700.559]
        
        Mitogen-Activated Protein Kinase Kinases [D08.811.913.696.620.682.700.565]
        
        Mitogen-Activated Protein Kinases [D08.811.913.696.620.682.700.567]
        
        Myotonin-Protein Kinase [D08.811.913.696.620.682.700.576]
        
        NF-kappaB-Inducing Kinase [D08.811.913.696.620.682.700.579]
        
        NIMA-Related Kinases [D08.811.913.696.620.682.700.581]
        
        Oncogene Protein v-akt [D08.811.913.696.620.682.700.586]
        
        p21-Activated Kinases [D08.811.913.696.620.682.700.596]
        
        Phytochrome A [D08.811.913.696.620.682.700.606]
        
        Polo-like Kinases [D08.811.913.696.620.682.700.616]
        
        Positive Transcriptional Elongation Factor B [D08.811.913.696.620.682.700.626]
        
        Proline-Directed Protein Kinases [D08.811.913.696.620.682.700.646]
        
        Protein Kinase C [D08.811.913.696.620.682.700.725]
        
        3-Phosphoinositide-Dependent Protein Kinases [D08.811.913.696.620.682.700.745]
        
        Protein Kinase D2 [D08.811.913.696.620.682.700.750]
        
        Proto-Oncogene Proteins c-akt [D08.811.913.696.620.682.700.755]
        
        Proto-Oncogene Proteins c-bcr [D08.811.913.696.620.682.700.759]
        
        Proto-Oncogene Proteins c-pim-1 [D08.811.913.696.620.682.700.776]
        
        PTEN-Induced Putative Kinase [D08.811.913.696.620.682.700.780]
        
        Pyruvate Dehydrogenase Acetyl-Transferring Kinase [D08.811.913.696.620.682.700.783]
        
        Receptor, Transforming Growth Factor-beta Type I [D08.811.913.696.620.682.700.789]
        
        Receptor, Transforming Growth Factor-beta Type II [D08.811.913.696.620.682.700.795]
        
        Receptor-Interacting Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700.801]
        
        rho-Associated Kinases [D08.811.913.696.620.682.700.814]
        
        Ribosomal Protein S6 Kinases [D08.811.913.696.620.682.700.862]
        
        Serine-Threonine Kinase 3 [D08.811.913.696.620.682.700.897]
        
        Serum-Glucocorticoid Regulated Kinases [D08.811.913.696.620.682.700.900]
        
        TOR Serine-Threonine Kinases [D08.811.913.696.620.682.700.931]
        
        Vacuolar Sorting Protein VPS15 [D08.811.913.696.620.682.700.965]
        
        WNK Lysine-Deficient Protein Kinase 1 [D08.811.913.696.620.682.700.982]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein Serine-Threonine Kinases [D12.776.476.563]

MAP-Kinase-Activated Kinase 2 Preferred

Concept UI: M000768898
Registry Numbers: EC 2.7.1.-
Scope Note: A serine-threonine protein kinase that functions in many different processes including the cellular response to PHYSIOLOGICAL STRESS, production of CYTOKINES; ENDOCYTOSIS; CYTOSKELETON dynamics, CELL MIGRATION; and CELL PROLIFERATION. It is phosphorylated by MAPK14 in response to stress, and in turn phosphorylates substrates at a SERINE that is preceded by a large hydrophobic amino acid.
Terms: MAP-Kinase-Activated Kinase 2 Preferred Term
Term UI T001148658
Date05/23/2025
LexicalTag NON
ThesaurusID NLM (1993); Heat Shock Protein 27 Kinase
Term UI T001147823
Date04/01/2025
LexicalTag NON
ThesaurusID NLM (1993); Heat-Shock Protein 27 Kinase
Term UI T001147824
Date04/01/2025
LexicalTag NON
ThesaurusID NLM (1993); HSP 27 Kinase
Term UI T001147825
Date04/01/2025
LexicalTag ABX
ThesaurusID NLM (1993); MAP-Kinase-Activated Protein Kinase 2
Term UI T001148659
Date05/23/2025
LexicalTag NON
ThesaurusID NLM (2026); MAPK Activated Protein Kinase 2
Term UI T001147834
Date04/01/2025
LexicalTag ABX
ThesaurusID NLM (2026); MAPKAP Kinase 2
Term UI T001147827
Date04/01/2025
LexicalTag ACX
ThesaurusID NLM (2003); MAPKAP Kinase-2
Term UI T001147828
Date04/01/2025
LexicalTag ACX
ThesaurusID NLM (1993); MAPKAPK-2
Term UI T617542
Date11/07/2004
LexicalTag ABB
ThesaurusID NLM (2004); MAPKAPK2
Term UI T253401
Date01/01/1955
LexicalTag ABB
ThesaurusID NLM (1993)

HSP25 Kinase Narrower

MAP-Kinase-Activated Kinase 2 MeSH Descriptor Data 2026