MeSH Browser

MeSH Heading: I-kappa B Kinase
Tree Number(s): D08.811.913.696.620.682.700.494; D12.776.476.563.494
Unique ID: D051550
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D051550
Scope Note: A protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit.
Entry Term(s): CHUK Kinase; Conserved Helix-Loop-Helix Ubiquitous Kinase; I Kappa B alpha-Associated Protein Kinase; I kappa B Kinase; IKBKB; IKK 1 Kinase; IKK 2 Kinase; IKK alpha; IKK beta; IKK epsilon; IKK gamma; IKKepsilon; IkappaB Kinase; IkappaB Kinase alpha; IkappaB Kinase beta; IkappaB Kinase epsilon; IkappaB Kinase gamma; IkappaBalpha Kinase; NF-kappaB Essential Modifier; NK-kappa B-Activating Kinase NAK
Related Numbers: EC 2.7.11.10
See Also: I-kappa B Proteins
Public MeSH Note: 2006; I-KAPPA B KINASE was indexed under PROTEIN-SERINE-THREONINE KINASES 1997-2005
History Note: 2006(1997)
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700]
        
        Activin Receptors [D08.811.913.696.620.682.700.062]
        
        AMP-Activated Protein Kinase Kinases [D08.811.913.696.620.682.700.074]
        
        AMP-Activated Protein Kinases [D08.811.913.696.620.682.700.085]
        
        Ataxia Telangiectasia Mutated Proteins [D08.811.913.696.620.682.700.097]
        
        Aurora Kinases [D08.811.913.696.620.682.700.103]
        
        Autophagy-Related Protein-1 Homolog [D08.811.913.696.620.682.700.108]
        
        Bone Morphogenetic Protein Receptors [D08.811.913.696.620.682.700.109]
        
        Calcium-Calmodulin-Dependent Protein Kinases [D08.811.913.696.620.682.700.125]
        
        Casein Kinases [D08.811.913.696.620.682.700.140]
        
        Checkpoint Kinase 1 [D08.811.913.696.620.682.700.143]
        
        Checkpoint Kinase 2 [D08.811.913.696.620.682.700.145]
        
        Cyclic Nucleotide-Regulated Protein Kinases [D08.811.913.696.620.682.700.150]
        
        DNA-Activated Protein Kinase [D08.811.913.696.620.682.700.250]
        
        Doublecortin-Like Kinases [D08.811.913.696.620.682.700.275]
        
        Dyrk Kinases [D08.811.913.696.620.682.700.288]
        
        eIF-2 Kinase [D08.811.913.696.620.682.700.300]
        
        G-Protein-Coupled Receptor Kinases [D08.811.913.696.620.682.700.364]
        
        Germinal Center Kinases [D08.811.913.696.620.682.700.397]
        
        Glycogen Synthase Kinases [D08.811.913.696.620.682.700.429]
        
        I-kappa B Kinase [D08.811.913.696.620.682.700.494]
        
        Interleukin-1 Receptor-Associated Kinases [D08.811.913.696.620.682.700.526]
        
        Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 [D08.811.913.696.620.682.700.534]
        
        Lim Kinases [D08.811.913.696.620.682.700.542]
        
        MAP Kinase Kinase Kinases [D08.811.913.696.620.682.700.559]
        
        Mitogen-Activated Protein Kinase Kinases [D08.811.913.696.620.682.700.565]
        
        Mitogen-Activated Protein Kinases [D08.811.913.696.620.682.700.567]
        
        Myotonin-Protein Kinase [D08.811.913.696.620.682.700.576]
        
        NF-kappaB-Inducing Kinase [D08.811.913.696.620.682.700.579]
        
        NIMA-Related Kinases [D08.811.913.696.620.682.700.581]
        
        Oncogene Protein v-akt [D08.811.913.696.620.682.700.586]
        
        p21-Activated Kinases [D08.811.913.696.620.682.700.596]
        
        Phytochrome A [D08.811.913.696.620.682.700.606]
        
        Polo-like Kinases [D08.811.913.696.620.682.700.616]
        
        Positive Transcriptional Elongation Factor B [D08.811.913.696.620.682.700.626]
        
        Proline-Directed Protein Kinases [D08.811.913.696.620.682.700.646]
        
        Protein Kinase C [D08.811.913.696.620.682.700.725]
        
        3-Phosphoinositide-Dependent Protein Kinases [D08.811.913.696.620.682.700.745]
        
        Protein Kinase D2 [D08.811.913.696.620.682.700.750]
        
        Proto-Oncogene Proteins c-akt [D08.811.913.696.620.682.700.755]
        
        Proto-Oncogene Proteins c-bcr [D08.811.913.696.620.682.700.759]
        
        Proto-Oncogene Proteins c-pim-1 [D08.811.913.696.620.682.700.776]
        
        Pyruvate Dehydrogenase Acetyl-Transferring Kinase [D08.811.913.696.620.682.700.783]
        
        Receptor, Transforming Growth Factor-beta Type I [D08.811.913.696.620.682.700.789]
        
        Receptor, Transforming Growth Factor-beta Type II [D08.811.913.696.620.682.700.795]
        
        Receptor-Interacting Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700.801]
        
        rho-Associated Kinases [D08.811.913.696.620.682.700.814]
        
        Ribosomal Protein S6 Kinases [D08.811.913.696.620.682.700.862]
        
        Serine-Threonine Kinase 3 [D08.811.913.696.620.682.700.897]
        
        TOR Serine-Threonine Kinases [D08.811.913.696.620.682.700.931]
        
        Vacuolar Sorting Protein VPS15 [D08.811.913.696.620.682.700.965]
        
        WNK Lysine-Deficient Protein Kinase 1 [D08.811.913.696.620.682.700.982]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein Serine-Threonine Kinases [D12.776.476.563]

I-kappa B Kinase Preferred

Concept UI: M0279189
Related Numbers: EC 2.7.11.10
Scope Note: A protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit.
Terms: I-kappa B Kinase Preferred Term
Term UI T637945
Date04/26/2005
LexicalTag NON
ThesaurusID NLM (2006); NK-kappa B-Activating Kinase NAK
Term UI T413572
Date05/08/2000
LexicalTag NON
ThesaurusID NLM (2006); IkappaB Kinase
Term UI T309190
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); I kappa B Kinase
Term UI T309194
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006)

IkappaB Kinase beta Narrower

Concept UI: M0279183
Terms: IkappaB Kinase beta Preferred Term
Term UI T521176
Date10/03/2002
LexicalTag NON
ThesaurusID NLM (2006); IKBKB
Term UI T309184
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); IKK 2 Kinase
Term UI T309186
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); IKK beta
Term UI T309188
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006)

IkappaB Kinase gamma Narrower

IkappaB Kinase alpha Narrower

Concept UI: M0279186
Terms: IkappaB Kinase alpha Preferred Term
Term UI T521175
Date10/03/2002
LexicalTag NON
ThesaurusID NLM (2006); IKK 1 Kinase
Term UI T309185
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); IKK alpha
Term UI T309187
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); I Kappa B alpha-Associated Protein Kinase
Term UI T309183
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); Conserved Helix-Loop-Helix Ubiquitous Kinase
Term UI T521178
Date10/03/2002
LexicalTag NON
ThesaurusID NLM (2006); CHUK Kinase
Term UI T363227
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); IkappaBalpha Kinase
Term UI T309191
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006)

IkappaB Kinase epsilon Narrower

I-kappa B Kinase MeSH Descriptor Data 2025