Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

NLM Logo

3-Phosphoinositide-Dependent Protein Kinases MeSH Descriptor Data 2026


MeSH Heading
3-Phosphoinositide-Dependent Protein Kinases
Tree Number(s)
D08.811.913.696.620.682.700.745
D12.776.476.563.745
Unique ID
D064413
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D064413
Scope Note
Highly conserved protein-serine threonine kinases that phosphorylate and activate a group of AGC protein kinases, especially in response to the production of the SECOND MESSENGERS, phosphatidylinositol 3,4,-biphosphate (PtdIns(3,4)P2) and phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3).
Entry Term(s)
3-Phosphoinositide Dependent Protein Kinase-1
3-Phosphoinositide Dependent Protein Kinase-2
3-Phosphoinositide-Dependent Kinase 1 (PDK1)
3-Phosphoinositide-Dependent Protein Kinase
3-Phosphoinositide-Dependent Protein Kinase-1
3-Phosphoinositide-Dependent Protein Kinase-2
PtdIns(3,4,5)P3-Dependent Protein Kinase-1
Registry Numbers
EC 2.7.11.1
EC 2.7.11.1
EC 2.7.11.1
Related Numbers
EC 2.7.11.1
Previous Indexing
Protein-Serine-Threonine Kinases (1997-2013)
Public MeSH Note
2014; 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE was indexed under PROTEIN-SERINE-THREONINE KINASES 1997-2013
History Note
2014
Date Introduced
2014/01/01
Last Updated
2021/05/20
3-Phosphoinositide-Dependent Protein Kinases Preferred
3-Phosphoinositide Dependent Protein Kinase-1 Narrower
3-Phosphoinositide Dependent Protein Kinase-2 Narrower
page delivered in 0.162s