MeSH Browser

MeSH Heading: Proto-Oncogene Proteins c-akt
Tree Number(s): D08.811.913.696.620.682.700.755; D12.776.476.563.755; D12.776.624.664.700.168
Unique ID: D051057
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D051057
Scope Note: Protein-serine-threonine kinases that contain PLECKSTRIN HOMOLOGY DOMAINS and are activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. They play a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.
Entry Term(s): AKT1 Protein Kinase; AKT2 Protein Kinase; AKT3 Protein Kinase; Akt-alpha Protein; Akt-beta Protein; Akt-gamma Protein; Protein Kinase B; Protein Kinase B alpha; Protein Kinase B beta; Protein Kinase B gamma; Protein-Serine-Threonine Kinase (Rac); Proto-Oncogene Protein Akt; Proto-Oncogene Protein RAC; Proto-Oncogene Proteins c-akt1; Proto-Oncogene Proteins c-akt2; Proto-Oncogene Proteins c-akt3; RAC-PK Protein; Rac Protein Kinase; Rac-PK alpha Protein; Rac-PK beta Protein; Related to A and C-Protein; akt Proto-Oncogene Protein; c-akt Protein; c-akt Proto-Oncogene Protein
Related Numbers: EC 2.7.11.1
Public MeSH Note: 2006; PROTO-ONCOGENE PROTEINS C-AKT was indexed under PROTEIN-SERINE-THREONINE KINASES & PROTO-ONCOGENE PROTEINS 1987-2005
History Note: 2006(1987)
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700]
        
        Activin Receptors [D08.811.913.696.620.682.700.062]
        
        AMP-Activated Protein Kinase Kinases [D08.811.913.696.620.682.700.074]
        
        AMP-Activated Protein Kinases [D08.811.913.696.620.682.700.085]
        
        Ataxia Telangiectasia Mutated Proteins [D08.811.913.696.620.682.700.097]
        
        Aurora Kinases [D08.811.913.696.620.682.700.103]
        
        Autophagy-Related Protein-1 Homolog [D08.811.913.696.620.682.700.108]
        
        Bone Morphogenetic Protein Receptors [D08.811.913.696.620.682.700.109]
        
        Calcium-Calmodulin-Dependent Protein Kinases [D08.811.913.696.620.682.700.125]
        
        Casein Kinases [D08.811.913.696.620.682.700.140]
        
        Checkpoint Kinase 1 [D08.811.913.696.620.682.700.143]
        
        Checkpoint Kinase 2 [D08.811.913.696.620.682.700.145]
        
        Cyclic Nucleotide-Regulated Protein Kinases [D08.811.913.696.620.682.700.150]
        
        DNA-Activated Protein Kinase [D08.811.913.696.620.682.700.250]
        
        Doublecortin-Like Kinases [D08.811.913.696.620.682.700.275]
        
        Dyrk Kinases [D08.811.913.696.620.682.700.288]
        
        eIF-2 Kinase [D08.811.913.696.620.682.700.300]
        
        G-Protein-Coupled Receptor Kinases [D08.811.913.696.620.682.700.364]
        
        Germinal Center Kinases [D08.811.913.696.620.682.700.397]
        
        Glycogen Synthase Kinases [D08.811.913.696.620.682.700.429]
        
        I-kappa B Kinase [D08.811.913.696.620.682.700.494]
        
        Interleukin-1 Receptor-Associated Kinases [D08.811.913.696.620.682.700.526]
        
        Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 [D08.811.913.696.620.682.700.534]
        
        Lim Kinases [D08.811.913.696.620.682.700.542]
        
        MAP Kinase Kinase Kinases [D08.811.913.696.620.682.700.559]
        
        Mitogen-Activated Protein Kinase Kinases [D08.811.913.696.620.682.700.565]
        
        Mitogen-Activated Protein Kinases [D08.811.913.696.620.682.700.567]
        
        Myotonin-Protein Kinase [D08.811.913.696.620.682.700.576]
        
        NF-kappaB-Inducing Kinase [D08.811.913.696.620.682.700.579]
        
        NIMA-Related Kinases [D08.811.913.696.620.682.700.581]
        
        Oncogene Protein v-akt [D08.811.913.696.620.682.700.586]
        
        p21-Activated Kinases [D08.811.913.696.620.682.700.596]
        
        Phytochrome A [D08.811.913.696.620.682.700.606]
        
        Polo-like Kinases [D08.811.913.696.620.682.700.616]
        
        Positive Transcriptional Elongation Factor B [D08.811.913.696.620.682.700.626]
        
        Proline-Directed Protein Kinases [D08.811.913.696.620.682.700.646]
        
        Protein Kinase C [D08.811.913.696.620.682.700.725]
        
        3-Phosphoinositide-Dependent Protein Kinases [D08.811.913.696.620.682.700.745]
        
        Protein Kinase D2 [D08.811.913.696.620.682.700.750]
        
        Proto-Oncogene Proteins c-akt [D08.811.913.696.620.682.700.755]
        
        Proto-Oncogene Proteins c-bcr [D08.811.913.696.620.682.700.759]
        
        Proto-Oncogene Proteins c-pim-1 [D08.811.913.696.620.682.700.776]
        
        Pyruvate Dehydrogenase Acetyl-Transferring Kinase [D08.811.913.696.620.682.700.783]
        
        Receptor, Transforming Growth Factor-beta Type I [D08.811.913.696.620.682.700.789]
        
        Receptor, Transforming Growth Factor-beta Type II [D08.811.913.696.620.682.700.795]
        
        Receptor-Interacting Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700.801]
        
        rho-Associated Kinases [D08.811.913.696.620.682.700.814]
        
        Ribosomal Protein S6 Kinases [D08.811.913.696.620.682.700.862]
        
        Serine-Threonine Kinase 3 [D08.811.913.696.620.682.700.897]
        
        TOR Serine-Threonine Kinases [D08.811.913.696.620.682.700.931]
        
        Vacuolar Sorting Protein VPS15 [D08.811.913.696.620.682.700.965]
        
        WNK Lysine-Deficient Protein Kinase 1 [D08.811.913.696.620.682.700.982]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein Serine-Threonine Kinases [D12.776.476.563]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Neoplasm Proteins [D12.776.624]
    - Oncogene Proteins [D12.776.624.664]
      - Proto-Oncogene Proteins [D12.776.624.664.700]
        
        Axl Receptor Tyrosine Kinase [D12.776.624.664.700.013]
        
        Bcl-2-Like Protein 11 [D12.776.624.664.700.025]
        
        c-Mer Tyrosine Kinase [D12.776.624.664.700.037]
        
        Chemokine CXCL1 [D12.776.624.664.700.049]
        
        Cyclin D1 [D12.776.624.664.700.100]
        
        Fibroblast Growth Factor 4 [D12.776.624.664.700.110]
        
        Fibroblast Growth Factor 6 [D12.776.624.664.700.112]
        
        fms-Like Tyrosine Kinase 3 [D12.776.624.664.700.114]
        
        Janus Kinase 2 [D12.776.624.664.700.117]
        
        KRIT1 Protein [D12.776.624.664.700.119]
        
        Kruppel-Like Factor 6 [D12.776.624.664.700.120]
        
        Lipocalin-2 [D12.776.624.664.700.123]
        
        Lymphocyte Specific Protein Tyrosine Kinase p56(lck) [D12.776.624.664.700.128]
        
        MDS1 and EVI1 Complex Locus Protein [D12.776.624.664.700.129]
        
        MutS Homolog 2 Protein [D12.776.624.664.700.130]
        
        Myeloid-Lymphoid Leukemia Protein [D12.776.624.664.700.148]
        
        N-Myc Proto-Oncogene Protein [D12.776.624.664.700.158]
        
        Pre-B-Cell Leukemia Transcription Factor 1 [D12.776.624.664.700.163]
        
        B-Cell Lymphoma 3 Protein [D12.776.624.664.700.165]
        
        Proto-Oncogene Mas [D12.776.624.664.700.166]
        
        Proto-Oncogene Proteins c-abl [D12.776.624.664.700.167]
        
        Proto-Oncogene Proteins c-akt [D12.776.624.664.700.168]
        
        Proto-Oncogene Proteins c-bcl-2 [D12.776.624.664.700.169]
        
        Proto-Oncogene Proteins c-bcl-6 [D12.776.624.664.700.170]
        
        Proto-Oncogene Proteins c-bcr [D12.776.624.664.700.171]
        
        Proto-Oncogene Proteins c-cbl [D12.776.624.664.700.172]
        
        Proto-Oncogene Proteins c-crk [D12.776.624.664.700.174]
        
        Proto-Oncogene Proteins c-ets [D12.776.624.664.700.175]
        
        Proto-Oncogene Proteins c-fes [D12.776.624.664.700.177]
        
        Proto-Oncogene Proteins c-fos [D12.776.624.664.700.179]
        
        Proto-Oncogene Proteins c-fyn [D12.776.624.664.700.180]
        
        Proto-Oncogene Proteins c-hck [D12.776.624.664.700.181]
        
        Proto-Oncogene Proteins c-jun [D12.776.624.664.700.182]
        
        Proto-Oncogene Proteins c-kit [D12.776.624.664.700.183]
        
        Proto-Oncogene Proteins c-maf [D12.776.624.664.700.184]
        
        Proto-Oncogene Proteins c-mdm2 [D12.776.624.664.700.185]
        
        Proto-Oncogene Proteins c-met [D12.776.624.664.700.186]
        
        Proto-Oncogene Proteins c-mos [D12.776.624.664.700.187]
        
        Proto-Oncogene Proteins c-myb [D12.776.624.664.700.188]
        
        Proto-Oncogene Proteins c-myc [D12.776.624.664.700.189]
        
        Proto-Oncogene Proteins c-pim-1 [D12.776.624.664.700.191]
        
        Proto-Oncogene Proteins c-rel [D12.776.624.664.700.192]
        
        Proto-Oncogene Proteins c-ret [D12.776.624.664.700.194]
        
        Proto-Oncogene Proteins c-sis [D12.776.624.664.700.195]
        
        Proto-Oncogene Proteins c-vav [D12.776.624.664.700.198]
        
        Proto-Oncogene Proteins c-yes [D12.776.624.664.700.199]
        
        Proto-Oncogene Proteins p21(ras) [D12.776.624.664.700.200]
        
        Proto-Oncogene Proteins pp60(c-src) [D12.776.624.664.700.202]
        
        raf Kinases [D12.776.624.664.700.204]
        
        Receptor, ErbB-2 [D12.776.624.664.700.642]
        
        Receptor, ErbB-3 [D12.776.624.664.700.790]
        
        Receptor, ErbB-4 [D12.776.624.664.700.791]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D12.776.624.664.700.792]
        
        Receptor, Macrophage Colony-Stimulating Factor [D12.776.624.664.700.800]
        
        Receptor, Notch4 [D12.776.624.664.700.815]
        
        Receptors, Thyroid Hormone [D12.776.624.664.700.830]
        
        RNA-Binding Protein EWS [D12.776.624.664.700.913]
        
        RNA-Binding Protein FUS [D12.776.624.664.700.915]
        
        RUNX1 Translocation Partner 1 Protein [D12.776.624.664.700.936]
        
        Stathmin [D12.776.624.664.700.957]
        
        T-Cell Acute Lymphocytic Leukemia Protein 1 [D12.776.624.664.700.960]
        
        Wnt-5a Protein [D12.776.624.664.700.962]
        
        Wnt1 Protein [D12.776.624.664.700.967]
        
        Wnt2 Protein [D12.776.624.664.700.978]
        
        Zinc Finger Protein GLI1 [D12.776.624.664.700.989]

Proto-Oncogene Proteins c-akt Preferred

Concept UI: M0150739
Related Numbers: EC 2.7.11.1
Scope Note: Protein-serine-threonine kinases that contain PLECKSTRIN HOMOLOGY DOMAINS and are activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. They play a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.
Terms: Proto-Oncogene Proteins c-akt Preferred Term
Term UI T627282
Date01/10/2005
LexicalTag ACX
ThesaurusID NLM (2006); Protein Kinase B
Term UI T180741
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); Proto-Oncogene Protein RAC
Term UI T180743
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2006); Proto-Oncogene Protein Akt
Term UI T180744
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2006); Rac Protein Kinase
Term UI T229297
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2006); Protein-Serine-Threonine Kinase (Rac)
Term UI T229301
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2006); c-akt Proto-Oncogene Protein
Term UI T637364
Date04/21/2005
LexicalTag ABX
ThesaurusID NLM (2006); akt Proto-Oncogene Protein
Term UI T637365
Date04/21/2005
LexicalTag ABX
ThesaurusID NLM (2006); RAC-PK Protein
Term UI T627284
Date01/10/2005
LexicalTag ACX
ThesaurusID NLM (2006); c-akt Protein
Term UI T180740
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2006); Related to A and C-Protein
Term UI T627285
Date01/10/2005
LexicalTag NON
ThesaurusID NLM (2006)

Proto-Oncogene Proteins c-akt1 Narrower

Concept UI: M0283975
Terms: Proto-Oncogene Proteins c-akt1 Preferred Term
Term UI T631680
Date02/25/2005
LexicalTag ABX
ThesaurusID NLM (2006); Protein Kinase B alpha
Term UI T313979
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); AKT1 Protein Kinase
Term UI T313980
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2006); Akt-alpha Protein
Term UI T627295
Date01/10/2005
LexicalTag ACX
ThesaurusID NLM (2006); Rac-PK alpha Protein
Term UI T627306
Date01/10/2005
LexicalTag ACX
ThesaurusID NLM (2006)

Proto-Oncogene Proteins c-akt3 Narrower

Concept UI: M0479107
Terms: Proto-Oncogene Proteins c-akt3 Preferred Term
Term UI T631682
Date02/25/2005
LexicalTag ABX
ThesaurusID NLM (2006); AKT3 Protein Kinase
Term UI T627291
Date01/10/2005
LexicalTag ACX
ThesaurusID NLM (2006); Protein Kinase B gamma
Term UI T627292
Date01/10/2005
LexicalTag NON
ThesaurusID NLM (2006); Akt-gamma Protein
Term UI T627297
Date01/10/2005
LexicalTag ACX
ThesaurusID NLM (2006)

Proto-Oncogene Proteins c-akt2 Narrower

Concept UI: M0479108
Terms: Proto-Oncogene Proteins c-akt2 Preferred Term
Term UI T631681
Date02/25/2005
LexicalTag ABX
ThesaurusID NLM (2006); AKT2 Protein Kinase
Term UI T627293
Date01/10/2005
LexicalTag ACX
ThesaurusID NLM (2006); Protein Kinase B beta
Term UI T627294
Date01/10/2005
LexicalTag NON
ThesaurusID NLM (2006); Akt-beta Protein
Term UI T627296
Date01/10/2005
LexicalTag ACX
ThesaurusID NLM (2006); Rac-PK beta Protein
Term UI T627307
Date01/10/2005
LexicalTag ACX
ThesaurusID NLM (2006)

Proto-Oncogene Proteins c-akt MeSH Descriptor Data 2025