MeSH Browser

MeSH Heading: Insulin
Tree Number(s): D06.472.699.587.200.500.625; D12.644.548.586.200.500.625
Unique ID: D007328
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007328
Annotation: /blood: consider also HYPERINSULINEMIA (excessively high blood insulin levels) but do not confuse with HYPERINSULINISM (excessive secretion of insulin by pancreas); /‌immunology: consider also INSULIN ANTIBODIES; precursor = PROINSULIN; INSULIN INFUSION SYSTEMS is available
Scope Note: A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Entry Term(s): Iletin; Insulin A Chain; Insulin B Chain; Insulin, Regular; Novolin; Sodium Insulin; Soluble Insulin
Pharm Action: Hypoglycemic Agents
NLM Classification #: WK 802
See Also: Hyperinsulinism; Nonsuppressible Insulin-Like Activity; Proinsulin; Receptor, Insulin
Entry Combination: antagonists & inhibitors:Insulin Antagonists
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2011/06/24

Entry Combination: antagonists & inhibitors:Insulin Antagonists
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0011417
Scope Note: A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Terms: Insulin Preferred Term
Term UI T021939
Date01/01/1999
LexicalTag NON
ThesaurusID; Insulin, Regular
Term UI T493682
Date05/14/2002
LexicalTag NON
ThesaurusID NLM (2003); Soluble Insulin
Term UI T790029
Date05/02/2011
LexicalTag NON
ThesaurusID NLM (2012)

Insulin MeSH Descriptor Data 2025