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Insulin MeSH Descriptor Data 2023


MeSH Heading
Insulin
Tree Number(s)
D06.472.699.587.200.500.625
D12.644.548.586.200.500.625
Unique ID
D007328
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D007328
Annotation
/blood: consider also HYPERINSULINEMIA (excessively high blood insulin levels) but do not confuse with HYPERINSULINISM (excessive secretion of insulin by pancreas); /‌immunology: consider also INSULIN ANTIBODIES; precursor = PROINSULIN; INSULIN INFUSION SYSTEMS is available
Scope Note
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Entry Term(s)
Iletin
Insulin A Chain
Insulin B Chain
Insulin, Regular
Novolin
Sodium Insulin
Soluble Insulin
Pharm Action
Hypoglycemic Agents
Registry Number
0
NLM Classification #
WK 802
See Also
Hyperinsulinism
Nonsuppressible Insulin-Like Activity
Proinsulin
Receptor, Insulin
Entry Combination
antagonists & inhibitors:Insulin Antagonists
Date Established
1966/01/01
Date of Entry
1999/01/01
Revision Date
2011/06/24
Insulin Preferred
Insulin A Chain Narrower
Sodium Insulin Narrower
Novolin Narrower
Iletin Narrower
Insulin B Chain Narrower
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