MeSH Browser

MeSH Heading: C-Peptide
Tree Number(s): D06.472.699.587.200.500.250; D12.644.548.586.200.500.250
Unique ID: D002096
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D002096
Annotation: from proinsulin only: not for peptide fragments from other proteins ( = PEPTIDE FRAGMENTS)
Scope Note: The middle segment of proinsulin that is between the N-terminal B-chain and the C-terminal A-chain. It is a pancreatic peptide of about 31 residues, depending on the species. Upon proteolytic cleavage of proinsulin, equimolar INSULIN and C-peptide are released. C-peptide immunoassay has been used to assess pancreatic beta cell function in diabetic patients with circulating insulin antibodies or exogenous insulin. Half-life of C-peptide is 30 min, almost 8 times that of insulin.
Entry Term(s): C-Peptide, Proinsulin; Connecting Peptide; Proinsulin C-Peptide
NLM Classification #: WK 802
Previous Indexing: Peptides (1973-1976); Proinsulin (1975-1976)
Public MeSH Note: 84; was see under PEPTIDES 1977-83
History Note: 84(77); was see under PEPTIDES 1977-83
Date Established: 1984/01/01
Date of Entry: 1976/04/16
Revision Date: 2011/06/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0003121
Scope Note: The middle segment of proinsulin that is between the N-terminal B-chain and the C-terminal A-chain. It is a pancreatic peptide of about 31 residues, depending on the species. Upon proteolytic cleavage of proinsulin, equimolar INSULIN and C-peptide are released. C-peptide immunoassay has been used to assess pancreatic beta cell function in diabetic patients with circulating insulin antibodies or exogenous insulin. Half-life of C-peptide is 30 min, almost 8 times that of insulin.
Terms: C-Peptide Preferred Term
Term UI T005953
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1977); C-Peptide, Proinsulin
Term UI T669582
Date03/27/2006
LexicalTag NON
ThesaurusID NLM (2007); Connecting Peptide
Term UI T005954
Date04/14/1976
LexicalTag NON
ThesaurusID UNK (19XX); Proinsulin C-Peptide
Term UI T669583
Date03/27/2006
LexicalTag NON
ThesaurusID NLM (2007)

C-Peptide MeSH Descriptor Data 2025