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Proinsulin MeSH Descriptor Data 2023


MeSH Heading
Proinsulin
Tree Number(s)
D06.472.699.587.200.500
D12.644.548.586.200.500
D12.776.811.706
Unique ID
D011384
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D011384
Scope Note
A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the PANCREATIC BETA CELLS, is comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide are the secreted products. Intact proinsulin with low bioactivity also is secreted in small amounts.
Registry Number
9035-68-1
CAS Type 1 Name
Proinsulin
NLM Classification #
WK 802
Previous Indexing
Insulin (1966-1971)
Public MeSH Note
72
History Note
72
Date Established
1972/01/01
Date of Entry
1999/01/01
Revision Date
2011/06/24
Proinsulin Preferred
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