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Angiotensinogen MeSH Descriptor Data 2023


MeSH Heading
Angiotensinogen
Tree Number(s)
D12.644.456.073.070
D12.644.861.020
D12.776.811.070
D12.776.872.020
Unique ID
D000808
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000808
Scope Note
An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver in response to lowered blood pressure and secreted into blood circulation. Angiotensinogen is the inactive precursor of the ANGIOTENSINS produced in the body by successive enzyme cleavages. Cleavage of angiotensinogen by RENIN yields the decapeptide ANGIOTENSIN I. Further cleavage of angiotensin I (by ANGIOTENSIN CONVERTING ENZYME) yields the potent vasoconstrictor octapeptide ANGIOTENSIN II; and then, via other enzymes, other angiotensins also involved in the hemodynamic-regulating RENIN-ANGIOTENSIN SYSTEM.
Entry Term(s)
Hypertensinogen
Proangiotensin
Renin Substrate Tetradecapeptide
Renin-Substrate
SERPINA8
Serpin A8
Pharm Action
Serine Proteinase Inhibitors
Registry Number
11002-13-4
CAS Type 1 Name
Angiotensinogen (protein renin substrate)
NLM Classification #
QU 68
Previous Indexing
Alpha Globulins (1968-1974)
Angiotensin II (1968-1974)
Protein Precursors (1971-1974)
Public MeSH Note
87; was see under ANGIOTENSINS 1975-86
History Note
87(75); was see under ANGIOTENSINS 1975-86
Date Established
1987/01/01
Date of Entry
1974/11/19
Revision Date
2020/06/09
Angiotensinogen Preferred
Renin Substrate Tetradecapeptide Narrower
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