MeSH Browser

MeSH Heading: Factor VIII
Tree Number(s): D12.776.124.125.350; D12.776.811.286; D23.119.350
Unique ID: D005169
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D005169
Scope Note: Factor VIII of blood coagulation. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.
Entry Term(s): Blood Coagulation Factor VIII; Coagulation Factor VIII; F VIII-C; Factor 8; Factor 8 C; Factor Eight; Factor VIII Clotting Antigen; Factor VIII Coagulant Antigen; Factor VIII Procoagulant Activity; Factor VIIIC; Hyate-C; Hyatt-C; Thromboplastinogen
Pharm Action: Coagulants
CAS Type 1 Name: Blood-coagulation factor VIII, complex
NLM Classification #: WH 310
Entry Combination: deficiency:Hemophilia A
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2019/05/30

Entry Combination: deficiency:Hemophilia A
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0008146
Scope Note: Factor VIII of blood coagulation. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.
Terms: Factor VIII Preferred Term
Term UI T015802
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1966); Factor Eight
Term UI T000913545
Date01/04/2017
LexicalTag NON
ThesaurusID NLM (2018); Factor 8
Term UI T000913546
Date01/04/2017
LexicalTag NON
ThesaurusID NLM (2018); Thromboplastinogen
Term UI T015806
Date03/30/1974
LexicalTag NON
ThesaurusID UNK (19XX); Blood Coagulation Factor VIII
Term UI T015807
Date02/11/1997
LexicalTag NON
ThesaurusID NLM (1998); Coagulation Factor VIII
Term UI T015808
Date07/31/1996
LexicalTag NON
ThesaurusID NLM (1998)

Factor VIII MeSH Descriptor Data 2025