MeSH Browser

MeSH Heading: Pro-Opiomelanocortin
Tree Number(s): D06.472.699.327.935; D06.472.699.631.525.600; D12.644.400.400.935; D12.644.548.365.935; D12.644.548.691.525.690; D12.776.631.650.405.935; D12.776.811.800
Unique ID: D011333
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D011333
Scope Note: A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).
Entry Term(s): ACTH-Endorphin Precursor; ACTH-beta-Lipotropin Precursor; Corticotropin-beta-Lipotropin Precursor; Endorphin-ACTH Precursor; Opiocortin; POMC; Pre-POMC; Pre-pro-opiocortin; Preproopiomelanocortin; Pro-ACTH-Endorphin; Pro-Opio-Melanocortin; Pro-Opiocortin; Proopiocortin; Proopiomelanocortin
Registry Numbers: 66796-54-1; 76775-14-9; 78321-08-1
Related Numbers: 76775-14-9; 78321-08-1
CAS Type 1 Name: Opiomelanocortin, pro-
Previous Indexing: Pituitary Hormones, Anterior (1966-1984); Protein Precursors (1973-1984)
Public MeSH Note: 1985; PRE-PRO-OPIOCORTIN was indexed under PRO-OPIOMELANOCORTIN & PROTEIN PRECURSORS 1980-2007; OPIOCORTIN was indexed under PRO-OPIOMELANOCORTIN 1987-2007
History Note: 1985
Date Established: 1985/01/01
Date of Entry: 1984/05/30
Revision Date: 2015/11/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
- Hormones [D06.472]
  - Peptide Hormones [D06.472.699]
    - Hypothalamic Hormones [D06.472.699.327]

Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
- Hormones [D06.472]
  - Peptide Hormones [D06.472.699]
    - Pituitary Hormones [D06.472.699.631]
      - Pituitary Hormones, Anterior [D06.472.699.631.525]
        
        Gonadotropins, Pituitary [D06.472.699.631.525.343]
        
        Growth Hormone [D06.472.699.631.525.425]
        
        Prolactin [D06.472.699.631.525.525]
        
        Pro-Opiomelanocortin [D06.472.699.631.525.600]
        
        alpha-Endorphin [D06.472.699.631.525.600.119]
        
        alpha-MSH [D06.472.699.631.525.600.179]
        
        beta-Endorphin [D06.472.699.631.525.600.239]
        
        beta-Lipotropin [D06.472.699.631.525.600.480]
        
        Corticotropin-Like Intermediate Lobe Peptide [D06.472.699.631.525.600.498]
        
        gamma-Endorphin [D06.472.699.631.525.600.505]
        
        gamma-Lipotropin [D06.472.699.631.525.600.518]
        
        gamma-MSH [D06.472.699.631.525.600.524]
        
        Melanocortins [D06.472.699.631.525.600.531]
        
        Thyrotropin [D06.472.699.631.525.883]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Neuropeptides [D12.644.400]
    - Hypothalamic Hormones [D12.644.400.400]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Peptide Hormones [D12.644.548]
    - Hypothalamic Hormones [D12.644.548.365]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Peptide Hormones [D12.644.548]
    - Pituitary Hormones [D12.644.548.691]
      - Pituitary Hormones, Anterior [D12.644.548.691.525]
        
        Gonadotropins, Pituitary [D12.644.548.691.525.343]
        
        Growth Hormone [D12.644.548.691.525.425]
        
        Prolactin [D12.644.548.691.525.525]
        
        Pro-Opiomelanocortin [D12.644.548.691.525.690]
        
        alpha-Endorphin [D12.644.548.691.525.690.119]
        
        alpha-MSH [D12.644.548.691.525.690.179]
        
        beta-Endorphin [D12.644.548.691.525.690.239]
        
        beta-Lipotropin [D12.644.548.691.525.690.480]
        
        Corticotropin-Like Intermediate Lobe Peptide [D12.644.548.691.525.690.498]
        
        gamma-Endorphin [D12.644.548.691.525.690.505]
        
        gamma-Lipotropin [D12.644.548.691.525.690.518]
        
        gamma-MSH [D12.644.548.691.525.690.524]
        
        Melanocortins [D12.644.548.691.525.690.531]
        
        Thyrotropin [D12.644.548.691.525.883]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Nerve Tissue Proteins [D12.776.631]
    - Neuropeptides [D12.776.631.650]
      - Hypothalamic Hormones [D12.776.631.650.405]
        
        Pituitary Hormone Release Inhibiting Hormones [D12.776.631.650.405.700]
        
        Pituitary Hormone-Releasing Hormones [D12.776.631.650.405.740]
        
        Pro-Opiomelanocortin [D12.776.631.650.405.935]
        
        alpha-Endorphin [D12.776.631.650.405.935.119]
        
        alpha-MSH [D12.776.631.650.405.935.179]
        
        beta-Endorphin [D12.776.631.650.405.935.239]
        
        beta-Lipotropin [D12.776.631.650.405.935.480]
        
        Corticotropin-Like Intermediate Lobe Peptide [D12.776.631.650.405.935.498]
        
        gamma-Endorphin [D12.776.631.650.405.935.505]
        
        gamma-Lipotropin [D12.776.631.650.405.935.518]
        
        gamma-MSH [D12.776.631.650.405.935.524]
        
        Melanocortins [D12.776.631.650.405.935.531]
        
        Prolactin-Releasing Hormone [D12.776.631.650.405.967]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Protein Precursors [D12.776.811]

Pro-Opiomelanocortin Preferred

Concept UI: M0017593
Registry Numbers: 66796-54-1
Related Numbers: 76775-14-9; 78321-08-1
Scope Note: A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).
Terms: Pro-Opiomelanocortin Preferred Term
Term UI T033405
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1985); ACTH-beta-Lipotropin Precursor
Term UI T033399
Date05/30/1984
LexicalTag NON
ThesaurusID UNK (19XX); ACTH-Endorphin Precursor
Term UI T033400
Date05/30/1984
LexicalTag NON
ThesaurusID UNK (19XX); Endorphin-ACTH Precursor
Term UI T033401
Date05/30/1984
LexicalTag NON
ThesaurusID UNK (19XX); Corticotropin-beta-Lipotropin Precursor
Term UI T033402
Date05/30/1984
LexicalTag NON
ThesaurusID UNK (19XX); Pro-ACTH-Endorphin
Term UI T033404
Date05/30/1984
LexicalTag NON
ThesaurusID UNK (19XX); Pro-Opiocortin
Term UI T033406
Date05/30/1984
LexicalTag NON
ThesaurusID UNK (19XX); Pro-Opio-Melanocortin
Term UI T033407
Date05/30/1984
LexicalTag NON
ThesaurusID UNK (19XX); Proopiocortin
Term UI T033408
Date05/30/1984
LexicalTag NON
ThesaurusID UNK (19XX); POMC
Term UI T033403
Date05/30/1984
LexicalTag ABB
ThesaurusID UNK (19XX); Proopiomelanocortin
Term UI T033409
Date05/30/1984
LexicalTag NON
ThesaurusID UNK (19XX)

Preproopiomelanocortin Narrower

Opiocortin Narrower

Pro-Opiomelanocortin MeSH Descriptor Data 2025