MeSH Browser

MeSH Heading: alpha-MSH
Tree Number(s): D06.472.699.327.935.179; D06.472.699.327.935.531.750.050; D06.472.699.631.525.600.179; D06.472.699.631.525.600.531.750.050; D12.644.400.400.935.179; D12.644.400.400.935.531.750.050; D12.644.400.460.050; D12.644.548.365.935.179; D12.644.548.365.935.531.750.050; D12.644.548.691.525.690.179; D12.644.548.691.525.690.531.750.050; D12.776.631.650.405.935.179; D12.776.631.650.405.935.531.750.050; D12.776.631.650.460.050
Unique ID: D000521
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000521
Scope Note: A 13-amino acid peptide derived from proteolytic cleavage of ADRENOCORTICOTROPIC HORMONE, the N-terminal segment of ACTH. ACTH (1-13) is amidated at the C-terminal to form ACTH (1-13)NH2 which in turn is acetylated to form alpha-MSH in the secretory granules. Alpha-MSH stimulates the synthesis and distribution of MELANIN in MELANOCYTES in mammals and MELANOPHORES in lower vertebrates.
Entry Term(s): (Des-Acetyl)-alpha-MSH; (Desacetyl)alpha-MSH; ACTH (1-13); ACTH (1-13)NH2; ACTH(1-13); Acetylated ACTH (1-13)NH2; Adrenocorticotropin (1-13)NH2; DE-alpha-MSH; Des-Acetyl MSH; Desacetyl alpha-MSH; Desacetyl alpha-Melanocyte-Stimulating Hormone; MSH, (Desacetyl)alpha-; MSH, alpha; alpha Intermedin; alpha-Melanocyte-Stimulating Hormone; alpha-Melanotropin
Pharm Action: Hormones
CAS Type 1 Name: alpha-Melanotropin
Previous Indexing: MSH (1966-1987)
Public MeSH Note: 1988; ACTH (1-13) was indexed under PEPTIDE FRAGMENTS & ALPHA-MSH 1981-2006
History Note: 1988 (1981)
Date Established: 1988/01/01
Date of Entry: 1987/05/05
Revision Date: 2019/04/29

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
- Hormones [D06.472]
  - Peptide Hormones [D06.472.699]
    - Hypothalamic Hormones [D06.472.699.327]
      - Pro-Opiomelanocortin [D06.472.699.327.935]
        
        alpha-Endorphin [D06.472.699.327.935.119]
        
        alpha-MSH [D06.472.699.327.935.179]
        
        beta-Endorphin [D06.472.699.327.935.239]
        
        beta-Lipotropin [D06.472.699.327.935.480]
        
        Corticotropin-Like Intermediate Lobe Peptide [D06.472.699.327.935.498]
        
        gamma-Endorphin [D06.472.699.327.935.505]
        
        gamma-Lipotropin [D06.472.699.327.935.518]
        
        gamma-MSH [D06.472.699.327.935.524]
        
        Melanocortins [D06.472.699.327.935.531]

Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
- Hormones [D06.472]
  - Peptide Hormones [D06.472.699]
    - Hypothalamic Hormones [D06.472.699.327]
      - Pro-Opiomelanocortin [D06.472.699.327.935]
        
        Melanocortins [D06.472.699.327.935.531]
        
        Melanocyte-Stimulating Hormones [D06.472.699.327.935.531.750]
        
        alpha-MSH [D06.472.699.327.935.531.750.050]
        
        beta-MSH [D06.472.699.327.935.531.750.075]
        
        gamma-MSH [D06.472.699.327.935.531.750.115]

Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
- Hormones [D06.472]
  - Peptide Hormones [D06.472.699]
    - Pituitary Hormones [D06.472.699.631]
      - Pituitary Hormones, Anterior [D06.472.699.631.525]
        
        Pro-Opiomelanocortin [D06.472.699.631.525.600]
        
        alpha-Endorphin [D06.472.699.631.525.600.119]
        
        alpha-MSH [D06.472.699.631.525.600.179]
        
        beta-Endorphin [D06.472.699.631.525.600.239]
        
        beta-Lipotropin [D06.472.699.631.525.600.480]
        
        Corticotropin-Like Intermediate Lobe Peptide [D06.472.699.631.525.600.498]
        
        gamma-Endorphin [D06.472.699.631.525.600.505]
        
        gamma-Lipotropin [D06.472.699.631.525.600.518]
        
        gamma-MSH [D06.472.699.631.525.600.524]
        
        Melanocortins [D06.472.699.631.525.600.531]

Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
- Hormones [D06.472]
  - Peptide Hormones [D06.472.699]
    - Pituitary Hormones [D06.472.699.631]
      - Pituitary Hormones, Anterior [D06.472.699.631.525]
        
        Pro-Opiomelanocortin [D06.472.699.631.525.600]
        
        Melanocortins [D06.472.699.631.525.600.531]
        
        Melanocyte-Stimulating Hormones [D06.472.699.631.525.600.531.750]
        
        alpha-MSH [D06.472.699.631.525.600.531.750.050]
        
        beta-MSH [D06.472.699.631.525.600.531.750.075]
        
        gamma-MSH [D06.472.699.631.525.600.531.750.115]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Neuropeptides [D12.644.400]
    - Hypothalamic Hormones [D12.644.400.400]
      - Pro-Opiomelanocortin [D12.644.400.400.935]
        
        alpha-Endorphin [D12.644.400.400.935.119]
        
        alpha-MSH [D12.644.400.400.935.179]
        
        beta-Endorphin [D12.644.400.400.935.239]
        
        beta-Lipotropin [D12.644.400.400.935.480]
        
        Corticotropin-Like Intermediate Lobe Peptide [D12.644.400.400.935.498]
        
        gamma-Endorphin [D12.644.400.400.935.505]
        
        gamma-Lipotropin [D12.644.400.400.935.518]
        
        gamma-MSH [D12.644.400.400.935.524]
        
        Melanocortins [D12.644.400.400.935.531]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Neuropeptides [D12.644.400]
    - Hypothalamic Hormones [D12.644.400.400]
      - Pro-Opiomelanocortin [D12.644.400.400.935]
        
        Melanocortins [D12.644.400.400.935.531]
        
        Melanocyte-Stimulating Hormones [D12.644.400.400.935.531.750]
        
        alpha-MSH [D12.644.400.400.935.531.750.050]
        
        beta-MSH [D12.644.400.400.935.531.750.075]
        
        gamma-MSH [D12.644.400.400.935.531.750.115]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Neuropeptides [D12.644.400]
    - Melanocyte-Stimulating Hormones [D12.644.400.460]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Peptide Hormones [D12.644.548]
    - Hypothalamic Hormones [D12.644.548.365]
      - Pro-Opiomelanocortin [D12.644.548.365.935]
        
        alpha-Endorphin [D12.644.548.365.935.119]
        
        alpha-MSH [D12.644.548.365.935.179]
        
        beta-Endorphin [D12.644.548.365.935.239]
        
        beta-Lipotropin [D12.644.548.365.935.480]
        
        Corticotropin-Like Intermediate Lobe Peptide [D12.644.548.365.935.498]
        
        gamma-Endorphin [D12.644.548.365.935.505]
        
        gamma-Lipotropin [D12.644.548.365.935.518]
        
        gamma-MSH [D12.644.548.365.935.524]
        
        Melanocortins [D12.644.548.365.935.531]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Peptide Hormones [D12.644.548]
    - Hypothalamic Hormones [D12.644.548.365]
      - Pro-Opiomelanocortin [D12.644.548.365.935]
        
        Melanocortins [D12.644.548.365.935.531]
        
        Melanocyte-Stimulating Hormones [D12.644.548.365.935.531.750]
        
        alpha-MSH [D12.644.548.365.935.531.750.050]
        
        beta-MSH [D12.644.548.365.935.531.750.075]
        
        gamma-MSH [D12.644.548.365.935.531.750.115]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Peptide Hormones [D12.644.548]
    - Pituitary Hormones [D12.644.548.691]
      - Pituitary Hormones, Anterior [D12.644.548.691.525]
        
        Pro-Opiomelanocortin [D12.644.548.691.525.690]
        
        alpha-Endorphin [D12.644.548.691.525.690.119]
        
        alpha-MSH [D12.644.548.691.525.690.179]
        
        beta-Endorphin [D12.644.548.691.525.690.239]
        
        beta-Lipotropin [D12.644.548.691.525.690.480]
        
        Corticotropin-Like Intermediate Lobe Peptide [D12.644.548.691.525.690.498]
        
        gamma-Endorphin [D12.644.548.691.525.690.505]
        
        gamma-Lipotropin [D12.644.548.691.525.690.518]
        
        gamma-MSH [D12.644.548.691.525.690.524]
        
        Melanocortins [D12.644.548.691.525.690.531]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Peptide Hormones [D12.644.548]
    - Pituitary Hormones [D12.644.548.691]
      - Pituitary Hormones, Anterior [D12.644.548.691.525]
        
        Pro-Opiomelanocortin [D12.644.548.691.525.690]
        
        Melanocortins [D12.644.548.691.525.690.531]
        
        Melanocyte-Stimulating Hormones [D12.644.548.691.525.690.531.750]
        
        alpha-MSH [D12.644.548.691.525.690.531.750.050]
        
        beta-MSH [D12.644.548.691.525.690.531.750.075]
        
        gamma-MSH [D12.644.548.691.525.690.531.750.115]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Nerve Tissue Proteins [D12.776.631]
    - Neuropeptides [D12.776.631.650]
      - Hypothalamic Hormones [D12.776.631.650.405]
        
        Pro-Opiomelanocortin [D12.776.631.650.405.935]
        
        alpha-Endorphin [D12.776.631.650.405.935.119]
        
        alpha-MSH [D12.776.631.650.405.935.179]
        
        beta-Endorphin [D12.776.631.650.405.935.239]
        
        beta-Lipotropin [D12.776.631.650.405.935.480]
        
        Corticotropin-Like Intermediate Lobe Peptide [D12.776.631.650.405.935.498]
        
        gamma-Endorphin [D12.776.631.650.405.935.505]
        
        gamma-Lipotropin [D12.776.631.650.405.935.518]
        
        gamma-MSH [D12.776.631.650.405.935.524]
        
        Melanocortins [D12.776.631.650.405.935.531]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Nerve Tissue Proteins [D12.776.631]
    - Neuropeptides [D12.776.631.650]
      - Hypothalamic Hormones [D12.776.631.650.405]
        
        Pro-Opiomelanocortin [D12.776.631.650.405.935]
        
        Melanocortins [D12.776.631.650.405.935.531]
        
        Melanocyte-Stimulating Hormones [D12.776.631.650.405.935.531.750]
        
        alpha-MSH [D12.776.631.650.405.935.531.750.050]
        
        beta-MSH [D12.776.631.650.405.935.531.750.075]
        
        gamma-MSH [D12.776.631.650.405.935.531.750.115]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Nerve Tissue Proteins [D12.776.631]
    - Neuropeptides [D12.776.631.650]
      - Melanocyte-Stimulating Hormones [D12.776.631.650.460]
        
        alpha-MSH [D12.776.631.650.460.050]
        
        beta-MSH [D12.776.631.650.460.075]
        
        gamma-MSH [D12.776.631.650.460.115]

alpha-MSH Preferred

Concept UI: M0000797
Scope Note: A 13-amino acid peptide derived from proteolytic cleavage of ADRENOCORTICOTROPIC HORMONE, the N-terminal segment of ACTH. ACTH (1-13) is amidated at the C-terminal to form ACTH (1-13)NH2 which in turn is acetylated to form alpha-MSH in the secretory granules. Alpha-MSH stimulates the synthesis and distribution of MELANIN in MELANOCYTES in mammals and MELANOPHORES in lower vertebrates.
Terms: alpha-MSH Preferred Term
Term UI T001563
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1988); Acetylated ACTH (1-13)NH2
Term UI T664254
Date01/12/2006
LexicalTag ACX
ThesaurusID NLM (2007); alpha Intermedin
Term UI T000952110
Date02/22/2019
LexicalTag NON
ThesaurusID NLM (2020); alpha-Melanocyte-Stimulating Hormone
Term UI T001560
Date05/05/1987
LexicalTag NON
ThesaurusID UNK (19XX); alpha-Melanotropin
Term UI T001561
Date05/05/1987
LexicalTag NON
ThesaurusID UNK (19XX); MSH, alpha
Term UI T001562
Date05/05/1987
LexicalTag ACX
ThesaurusID UNK (19XX)

ACTH (1-13) Narrower

ACTH (1-13)NH2 Narrower

Concept UI: M0493894
Terms: ACTH (1-13)NH2 Preferred Term
Term UI T664255
Date01/12/2006
LexicalTag ACR
ThesaurusID NLM (2007); (Desacetyl)alpha-MSH
Term UI T122237
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2007); DE-alpha-MSH
Term UI T122239
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2007); MSH, (Desacetyl)alpha-
Term UI T122240
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2007); (Des-Acetyl)-alpha-MSH
Term UI T122236
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2007); Des-Acetyl MSH
Term UI T122242
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2007); Desacetyl alpha-MSH
Term UI T122243
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2007); Desacetyl alpha-Melanocyte-Stimulating Hormone
Term UI T122244
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2007); Adrenocorticotropin (1-13)NH2
Term UI T122241
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2007)

alpha-MSH MeSH Descriptor Data 2025