MeSH Browser

MeSH Heading: Fibrinogen
Tree Number(s): D12.776.124.050.250; D12.776.124.125.500; D12.776.811.300; D23.119.490
Unique ID: D005340
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D005340
Annotation: a blood coag factor: do not confuse entry term FACTOR I with COMPLEMENT FACTOR I
Scope Note: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.
Entry Term(s): Blood Coagulation Factor I; Coagulation Factor I; Factor I; gamma-Fibrinogen
CAS Type 1 Name: Fibrinogens
See Also: Coagulants; Hemostatics
Entry Combination: deficiency:Afibrinogenemia
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/06/28

Entry Combination: deficiency:Afibrinogenemia
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0008430
Scope Note: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.
Terms: Fibrinogen Preferred Term
Term UI T016300
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1966); Coagulation Factor I
Term UI T016298
Date07/31/1996
LexicalTag NON
ThesaurusID NLM (1998); Factor I
Term UI T016299
Date01/01/1975
LexicalTag NON
ThesaurusID UNK (19XX); Blood Coagulation Factor I
Term UI T016301
Date02/11/1997
LexicalTag NON
ThesaurusID NLM (1998)

Fibrinogen MeSH Descriptor Data 2025