MeSH Browser

MeSH Heading: Platelet Factor 4
Tree Number(s): D12.644.276.374.200.120.900; D12.776.124.125.720; D12.776.467.374.200.120.900; D23.119.940; D23.125.300.120.900; D23.469.200.120.900; D23.529.374.200.120.900
Unique ID: D010978
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D010978
Scope Note: A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C.
Entry Term(s): Antiheparin Factor; CXCL4 Chemokine; Chemokine CXCL4; Heparin Neutralizing Protein; PF4 (Platelet Factor 4); gamma-Thromboglobulin
Pharm Action: Coagulants
Registry Number: 37270-94-3
CAS Type 1 Name: Blood platelet factor 4
Previous Indexing: Blood Coagulation Factors (1973-1975); Blood Platelets (1974-1975); Glycoproteins (1974-1975)
Public MeSH Note: 84; was see under BLOOD COAGULATION FACTORS 1976-83
History Note: 84(76); was see under BLOOD COAGULATION FACTORS 1976-83
Date Established: 1984/01/01
Date of Entry: 1975/07/25
Revision Date: 2007/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0017019
Registry Number: 37270-94-3
Scope Note: A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C.
Terms: Platelet Factor 4 Preferred Term
Term UI T032322
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1976); Chemokine CXCL4
Term UI T687820
Date12/14/2006
LexicalTag ABX
ThesaurusID NLM (2008); PF4 (Platelet Factor 4)
Term UI T687823
Date12/14/2006
LexicalTag ABX
ThesaurusID NLM (2008); gamma-Thromboglobulin
Term UI T032319
Date03/31/1982
LexicalTag NON
ThesaurusID UNK (19XX); Heparin Neutralizing Protein
Term UI T032320
Date04/27/1981
LexicalTag NON
ThesaurusID UNK (19XX); Antiheparin Factor
Term UI T032318
Date07/25/1975
LexicalTag NON
ThesaurusID UNK (19XX); CXCL4 Chemokine
Term UI T687819
Date12/14/2006
LexicalTag ABX
ThesaurusID NLM (2008)

Platelet Factor 4 MeSH Descriptor Data 2023