MeSH Browser

MeSH Heading: Prothrombin
Tree Number(s): D08.622.709; D12.776.124.125.800; D12.776.811.243.709; D23.119.945
Unique ID: D011516
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D011516
Annotation: a blood coag factor; an enzyme precursor
Scope Note: A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.
Entry Term(s): Blood Coagulation Factor II; Coagulation Factor II; Differentiation Reversal Factor; Factor II
Registry Numbers: 9001-26-7
CAS Type 1 Name: Blood-coagulation factor II
See Also: Coagulants
Entry Combination: deficiency:Hypoprothrombinemias
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2019/05/30

Entry Combination: deficiency:Hypoprothrombinemias
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0017904
Registry Numbers: 9001-26-7
Scope Note: A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.
Terms: Prothrombin Preferred Term
Term UI T034022
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1966); Coagulation Factor II
Term UI T034020
Date07/31/1996
LexicalTag NON
ThesaurusID NLM (1998); Factor II
Term UI T034021
Date01/01/1975
LexicalTag NON
ThesaurusID UNK (19XX); Differentiation Reversal Factor
Term UI T034023
Date01/16/1991
LexicalTag NON
ThesaurusID NLM (1992); Blood Coagulation Factor II
Term UI T034024
Date02/11/1997
LexicalTag NON
ThesaurusID NLM (1998)

Prothrombin MeSH Descriptor Data 2025