MeSH Browser

MeSH Heading: Complement Factor B
Tree Number(s): D08.622.200; D08.811.277.656.300.760.198; D08.811.277.656.959.350.198; D12.776.124.486.274.900; D12.776.811.243.200
Unique ID: D011415
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D011415
Scope Note: A glycine-rich, heat-labile serum glycoprotein that contains a component of the C3 CONVERTASE ALTERNATE PATHWAY (C3bBb). Bb, a serine protease, is generated when factor B is cleaved by COMPLEMENT FACTOR D into Ba and Bb.
Entry Term(s): Bb Fragment of Factor B; C3 Proactivator; C3PA; Complement 3 Proactivator; Complement Factor B Fragment, Bb; Complement Factor B, Alternative Pathway; Complement Factor B-Derived Fragment Bb; Complement Factor Ba; Complement Factor Bb; Complement Protein B; Complement Protein Factor B; Factor B; Properdin Factor B; Properdin Factor Ba; Properdin Factor Bb; Properdin Factor Bf; Properdin Factor Bf F1
Pharm Action: Immunologic Factors
Registry Numbers: EC 3.4.21.47; 0; EC 3.4.21.47
Related Numbers: EC 3.4.21.47
Previous Indexing: Complement 3 (1975-1977); Enzyme Precursors (1966-1977); Glycoproteins (1966-1977)
Public MeSH Note: 99; see PROPERDIN FACTOR B 1991-98, see ENZYME PRECURSORS 1978-90; for COMPLEMENT FACTOR B see PROPERDIN FACTOR B 1988-98
History Note: 99(78)
Date Established: 1991/01/01
Date of Entry: 1977/04/15
Revision Date: 2019/05/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzyme Precursors [D08.622]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Endopeptidases [D08.811.277.656.300]
        
        Serine Endopeptidases [D08.811.277.656.300.760]
        
        Acrosin [D08.811.277.656.300.760.030]
        
        Cathepsin G [D08.811.277.656.300.760.066]
        
        Chymases [D08.811.277.656.300.760.103]
        
        Chymotrypsin [D08.811.277.656.300.760.176]
        
        Complement Factor B [D08.811.277.656.300.760.198]
        
        Complement Factor D [D08.811.277.656.300.760.200]
        
        Complement Factor I [D08.811.277.656.300.760.210]
        
        Endopeptidase K [D08.811.277.656.300.760.247]
        
        Enteropeptidase [D08.811.277.656.300.760.284]
        
        Factor VIIa [D08.811.277.656.300.760.300]
        
        Factor IXa [D08.811.277.656.300.760.310]
        
        Factor Xa [D08.811.277.656.300.760.315]
        
        Factor XIa [D08.811.277.656.300.760.320]
        
        Factor XIIa [D08.811.277.656.300.760.324]
        
        Fibrinolysin [D08.811.277.656.300.760.330]
        
        Furin [D08.811.277.656.300.760.353]
        
        Granzymes [D08.811.277.656.300.760.397]
        
        High-Temperature Requirement A Serine Peptidase 1 [D08.811.277.656.300.760.420]
        
        High-Temperature Requirement A Serine Peptidase 2 [D08.811.277.656.300.760.431]
        
        Kallikreins [D08.811.277.656.300.760.442]
        
        Lactoferrin [D08.811.277.656.300.760.471]
        
        Mannose-Binding Protein-Associated Serine Proteases [D08.811.277.656.300.760.501]
        
        Myeloblastin [D08.811.277.656.300.760.530]
        
        Pancreatic Elastase [D08.811.277.656.300.760.560]
        
        Plasminogen Activators [D08.811.277.656.300.760.635]
        
        Prolyl Oligopeptidases [D08.811.277.656.300.760.637]
        
        Pronase [D08.811.277.656.300.760.638]
        
        Proprotein Convertase 1 [D08.811.277.656.300.760.640]
        
        Proprotein Convertase 2 [D08.811.277.656.300.760.646]
        
        Proprotein Convertase 5 [D08.811.277.656.300.760.648]
        
        Proprotein Convertase 9 [D08.811.277.656.300.760.718]
        
        Reelin Protein [D08.811.277.656.300.760.753]
        
        Subtilisins [D08.811.277.656.300.760.787]
        
        Thrombin [D08.811.277.656.300.760.855]
        
        Tissue Plasminogen Activator [D08.811.277.656.300.760.875]
        
        Trypsin [D08.811.277.656.300.760.895]
        
        Tryptases [D08.811.277.656.300.760.902]
        
        Urokinase-Type Plasminogen Activator [D08.811.277.656.300.760.910]
        
        Venombin A [D08.811.277.656.300.760.955]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Serine Proteases [D08.811.277.656.959]
        
        Serine Endopeptidases [D08.811.277.656.959.350]
        
        Acrosin [D08.811.277.656.959.350.030]
        
        Cathepsin G [D08.811.277.656.959.350.066]
        
        Chymases [D08.811.277.656.959.350.103]
        
        Chymotrypsin [D08.811.277.656.959.350.176]
        
        Complement Factor B [D08.811.277.656.959.350.198]
        
        Complement Factor D [D08.811.277.656.959.350.200]
        
        Complement Factor I [D08.811.277.656.959.350.210]
        
        Endopeptidase K [D08.811.277.656.959.350.247]
        
        Enteropeptidase [D08.811.277.656.959.350.284]
        
        Factor VIIa [D08.811.277.656.959.350.300]
        
        Factor IXa [D08.811.277.656.959.350.310]
        
        Factor Xa [D08.811.277.656.959.350.315]
        
        Factor XIa [D08.811.277.656.959.350.320]
        
        Factor XIIa [D08.811.277.656.959.350.324]
        
        Fibrinolysin [D08.811.277.656.959.350.330]
        
        Furin [D08.811.277.656.959.350.353]
        
        Granzymes [D08.811.277.656.959.350.397]
        
        High-Temperature Requirement A Serine Peptidase 1 [D08.811.277.656.959.350.420]
        
        High-Temperature Requirement A Serine Peptidase 2 [D08.811.277.656.959.350.431]
        
        Kallikreins [D08.811.277.656.959.350.442]
        
        Lactoferrin [D08.811.277.656.959.350.471]
        
        Mannose-Binding Protein-Associated Serine Proteases [D08.811.277.656.959.350.501]
        
        Myeloblastin [D08.811.277.656.959.350.530]
        
        Pancreatic Elastase [D08.811.277.656.959.350.560]
        
        Plasminogen Activators [D08.811.277.656.959.350.635]
        
        Pronase [D08.811.277.656.959.350.638]
        
        Proprotein Convertase 1 [D08.811.277.656.959.350.640]
        
        Proprotein Convertase 2 [D08.811.277.656.959.350.646]
        
        Proprotein Convertase 5 [D08.811.277.656.959.350.648]
        
        Proprotein Convertase 9 [D08.811.277.656.959.350.718]
        
        Reelin Protein [D08.811.277.656.959.350.753]
        
        Subtilisins [D08.811.277.656.959.350.787]
        
        Thrombin [D08.811.277.656.959.350.855]
        
        Tissue Plasminogen Activator [D08.811.277.656.959.350.875]
        
        Trypsin [D08.811.277.656.959.350.895]
        
        Tryptases [D08.811.277.656.959.350.902]
        
        Urokinase-Type Plasminogen Activator [D08.811.277.656.959.350.910]
        
        Venombin A [D08.811.277.656.959.350.955]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Immunoproteins [D12.776.124.486]
      - Complement System Proteins [D12.776.124.486.274]
        
        Anaphylatoxins [D12.776.124.486.274.024]
        
        Complement Activating Enzymes [D12.776.124.486.274.045]
        
        Complement C1 [D12.776.124.486.274.050]
        
        Complement C2 [D12.776.124.486.274.150]
        
        Complement C3 [D12.776.124.486.274.250]
        
        Complement C4 [D12.776.124.486.274.350]
        
        Complement C5 [D12.776.124.486.274.450]
        
        Complement C6 [D12.776.124.486.274.550]
        
        Complement C7 [D12.776.124.486.274.650]
        
        Complement C8 [D12.776.124.486.274.750]
        
        Complement C9 [D12.776.124.486.274.850]
        
        Complement Factor B [D12.776.124.486.274.900]
        
        Complement Inactivator Proteins [D12.776.124.486.274.920]
        
        Complement Membrane Attack Complex [D12.776.124.486.274.930]
        
        Properdin [D12.776.124.486.274.965]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Protein Precursors [D12.776.811]
    - Enzyme Precursors [D12.776.811.243]

Complement Factor B Preferred

Concept UI: M0017749
Registry Numbers: EC 3.4.21.47
Related Numbers: EC 3.4.21.47
Scope Note: A glycine-rich, heat-labile serum glycoprotein that contains a component of the C3 CONVERTASE ALTERNATE PATHWAY (C3bBb). Bb, a serine protease, is generated when factor B is cleaved by COMPLEMENT FACTOR D into Ba and Bb.
Terms: Complement Factor B Preferred Term
Term UI T033686
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1978); Complement Factor B, Alternative Pathway
Term UI T033687
Date08/30/1982
LexicalTag NON
ThesaurusID UNK (19XX); Complement Protein B
Term UI T033688
Date08/12/1987
LexicalTag NON
ThesaurusID UNK (19XX); Complement Protein Factor B
Term UI T033689
Date10/07/1986
LexicalTag NON
ThesaurusID UNK (19XX); Factor B
Term UI T033691
Date09/12/1997
LexicalTag NON
ThesaurusID NLM (1999); Properdin Factor B
Term UI T033692
Date09/12/1997
LexicalTag NON
ThesaurusID NLM (1999); C3 Proactivator
Term UI T033693
Date04/07/1977
LexicalTag NON
ThesaurusID UNK (19XX); Complement 3 Proactivator
Term UI T033685
Date04/07/1977
LexicalTag NON
ThesaurusID UNK (19XX); C3PA
Term UI T033694
Date04/07/1977
LexicalTag ABB
ThesaurusID UNK (19XX)

Complement Factor Ba Narrower

Properdin Factor Bf Narrower

Properdin Factor Bf F1 Narrower

Complement Factor Bb Narrower

Concept UI: M0469165
Registry Numbers: EC 3.4.21.47
Terms: Complement Factor Bb Preferred Term
Term UI T620633
Date11/30/2004
LexicalTag NON
ThesaurusID NLM (2006); Properdin Factor Bb
Term UI T620634
Date11/30/2004
LexicalTag NON
ThesaurusID NLM (2006); Bb Fragment of Factor B
Term UI T195830
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); Complement Factor B-Derived Fragment Bb
Term UI T427464
Date10/28/2000
LexicalTag NON
ThesaurusID NLM (2006); Complement Factor B Fragment, Bb
Term UI T597163
Date07/16/2004
LexicalTag NON
ThesaurusID NLM (2006)

Complement Factor B MeSH Descriptor Data 2025