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Properdin MeSH Descriptor Data 2022


MeSH Heading
Properdin
Tree Number(s)
D12.776.124.486.274.965
D12.776.124.790.223.624
D12.776.377.715.182.624
Unique ID
D011414
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D011414
Scope Note
A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It stabilizes the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) and protects it from rapid inactivation, thus facilitating the cascade of COMPLEMENT ACTIVATION and the formation of MEMBRANE ATTACK COMPLEX. Individuals with mutation in the PFC gene exhibit properdin deficiency and have a high susceptibility to infections.
Entry Term(s)
Complement Factor P
Pharm Action
Immunologic Factors
Registry Number
11016-39-0
CAS Type 1 Name
Complement factor P
NLM Classification #
QW 680
Date Established
1966/01/01
Date of Entry
1999/01/01
Revision Date
2015/06/23
Properdin Preferred
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