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Complement C1 MeSH Descriptor Data 2023

MeSH Heading
Complement C1
Tree Number(s)
Unique ID
RDF Unique Identifier
/antag permitted but consider also COMPLEMENT C1 INACTIVATOR PROTEINS
Scope Note
The first complement component to act in the activation of CLASSICAL COMPLEMENT PATHWAY. It is a calcium-dependent trimolecular complex made up of three subcomponents: COMPLEMENT C1Q; COMPLEMENT C1R; and COMPLEMENT C1S at 1:2:2 ratios. When the intact C1 binds to at least two antibodies (involving C1q), C1r and C1s are sequentially activated, leading to subsequent steps in the cascade of COMPLEMENT ACTIVATION.
Entry Term(s)
C1 Complement
Complement 1
Complement Component 1
Pharm Action
Immunologic Factors
Registry Number
NLM Classification #
QW 680
Previous Indexing
Calcium (1966-1974)
Complement (1968-1974)
Public MeSH Note
2006; see COMPLEMENT 1 1978-2005, see COMPLEMENT 1975-1977
History Note
2006 (1975)
Date Established
Date of Entry
Revision Date
Complement C1 Preferred
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