MeSH Browser

MeSH Heading: Complement C2
Tree Number(s): D12.776.124.486.274.150
Unique ID: D003175
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D003175
Scope Note: A component of the CLASSICAL COMPLEMENT PATHWAY. C2 is cleaved by activated COMPLEMENT C1S into COMPLEMENT C2B and COMPLEMENT C2A. C2a, the COOH-terminal fragment containing a SERINE PROTEASE, combines with COMPLEMENT C4B to form C4b2a (CLASSICAL PATHWAY C3 CONVERTASE) and subsequent C4b2a3b (CLASSICAL PATHWAY C5 CONVERTASE).
Entry Term(s): C2 Complement; Complement 2; Complement Component 2
Pharm Action: Immunologic Factors
Registry Numbers: 0
Previous Indexing: Complement (1968-1974); Magnesium (1966-1974); Protein Binding (1966-1974)
Public MeSH Note: 2006; see COMPLEMENT 2 1978-2005, see COMPLEMENT 1975-1977
History Note: 2006 (1975)
Date Established: 1978/01/01
Date of Entry: 1974/11/11
Revision Date: 2005/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Complement C2 MeSH Descriptor Data 2025