MeSH Browser

MeSH Heading: Complement Membrane Attack Complex
Tree Number(s): D12.776.124.486.274.930
Unique ID: D015938
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015938
Scope Note: A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the membrane attack complex or MAC.
Entry Version: COMPLEMENT MAC
Entry Term(s): C 5b-9; C5b-8-poly-C9; C5b-9; Complement Complex C5b-9; Cytolytic Terminal Complement Complex; Membrane Attack Complex; Terminal Complement Complex
Pharm Action: Immunologic Factors
Previous Indexing: Complement (1973-1989)
Public MeSH Note: 90
History Note: 90
Date Established: 1990/01/01
Date of Entry: 1989/05/25
Revision Date: 2005/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0024383
Scope Note: A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the membrane attack complex or MAC.
Terms: Complement Membrane Attack Complex Preferred Term
Term UI T047297
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1990); C 5b-9
Term UI T047302
Date04/18/1989
LexicalTag NON
ThesaurusID NLM (1990); C5b-8-poly-C9
Term UI T620384
Date11/29/2004
LexicalTag NON
ThesaurusID NLM (2006); C5b-9
Term UI T047296
Date04/18/1989
LexicalTag NON
ThesaurusID NLM (1990); Complement Complex C5b-9
Term UI T047299
Date02/16/1990
LexicalTag NON
ThesaurusID NLM (1991); Cytolytic Terminal Complement Complex
Term UI T047300
Date01/14/1991
LexicalTag NON
ThesaurusID NLM (1992); Membrane Attack Complex
Term UI T047298
Date04/18/1989
LexicalTag NON
ThesaurusID NLM (1990); Terminal Complement Complex
Term UI T047301
Date01/14/1991
LexicalTag NON
ThesaurusID NLM (1992)

Complement Membrane Attack Complex MeSH Descriptor Data 2025