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Complement Membrane Attack Complex MeSH Descriptor Data 2023


MeSH Heading
Complement Membrane Attack Complex
Tree Number(s)
D12.776.124.486.274.930
Unique ID
D015938
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D015938
Scope Note
A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the "membrane attack complex" or MAC.
Entry Version
COMPLEMENT MAC
Entry Term(s)
C 5b-9
C5b-8-poly-C9
C5b-9
Complement Complex C5b-9
Cytolytic Terminal Complement Complex
Membrane Attack Complex
Terminal Complement Complex
Pharm Action
Immunologic Factors
Registry Number
0
Previous Indexing
Complement (1973-1989)
Public MeSH Note
90
History Note
90
Date Established
1990/01/01
Date of Entry
1989/05/25
Revision Date
2005/06/30
Complement Membrane Attack Complex Preferred
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