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Complement C5 MeSH Descriptor Data 2023

MeSH Heading
Complement C5
Tree Number(s)
Unique ID
RDF Unique Identifier
Scope Note
C5 plays a central role in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C5 is cleaved by C5 CONVERTASE into COMPLEMENT C5A and COMPLEMENT C5B. The smaller fragment C5a is an ANAPHYLATOXIN and mediator of inflammatory process. The major fragment C5b binds to the membrane initiating the spontaneous assembly of the late complement components, C5-C9, into the MEMBRANE ATTACK COMPLEX.
Entry Term(s)
C5 Complement
Complement 5
Complement C5, Precursor
Complement Component 5
Precursor C5
Pro-complement 5
Pharm Action
Immunologic Factors
Registry Number
Previous Indexing
Complement (1968-1974)
Histamine Liberation (1966-1974)
Public MeSH Note
2006; see COMPLEMENT 5 1978-2005, see COMPLEMENT 1975-1977; COMPLEMENT C5, PRECURSOR was indexed under COMPLEMENT 5 1991-2005
History Note
2006 (1975)
Date Established
Date of Entry
Revision Date
Complement C5 Preferred
Complement C5, Precursor Broader
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