MeSH Browser

MeSH Heading: Complement C3
Tree Number(s): D12.776.124.050.140; D12.776.124.486.274.250
Unique ID: D003176
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D003176
Scope Note: A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase.
Entry Term(s): C3 Complement; C3 Precursor; Complement 3; Complement C3 Precursor; Complement Component 3; Precursor-Complement 3; Pro-C3; Pro-Complement 3
Pharm Action: Immunologic Factors
NLM Classification #: QW 680
Previous Indexing: Anaphylaxis (1966-1974); Chemotaxis (1966-1974); Complement (1968-1974); Immune Adherence Reaction (1971-1974); Neutrophils (1966-1974); Phagocytosis (1966-1974)
Public MeSH Note: 2006; see COMPLEMENT 3 1978-2005, see COMPLEMENT 1975-1977; COMPLEMENT C3 PRECURSOR was indexed under COMPLEMENT 3 1982-2005
History Note: 2006 (1975)
Date Established: 1978/01/01
Date of Entry: 1974/11/11
Revision Date: 2005/07/11

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0004928
Scope Note: A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase.
Terms: Complement C3 Preferred Term
Term UI T623496
Date12/13/2004
LexicalTag NON
ThesaurusID NLM (2006); C3 Complement
Term UI T631382
Date02/23/2005
LexicalTag NON
ThesaurusID NLM (2006); Complement 3
Term UI T009268
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); Complement Component 3
Term UI T623497
Date12/13/2004
LexicalTag NON
ThesaurusID NLM (2006)

Concept UI: M0102971
Terms: Complement C3 Precursor Preferred Term
Term UI T597322
Date07/16/2004
LexicalTag NON
ThesaurusID NLM (2006); Pro-Complement 3
Term UI T132975
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); C3 Precursor
Term UI T132971
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); Precursor-Complement 3
Term UI T132972
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); Pro-C3
Term UI T132974
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006)

Complement C3 MeSH Descriptor Data 2025