MeSH Browser

MeSH Heading: Complement C7
Tree Number(s): D12.776.124.486.274.650
Unique ID: D003184
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D003184
Scope Note: A 93-kDa serum glycoprotein encoded by C7 gene. It is a polypeptide chain with 28 disulfide bridges. In the formation of MEMBRANE ATTACK COMPLEX; C7 is the next component to bind the C5b-6 complex forming a trimolecular complex C5b-7 which is lipophilic, resembles an integral membrane protein, and serves as an anchor for the late complement components, C8 and C9.
Entry Term(s): C7 Complement; Complement 7; Complement Component 7
Pharm Action: Immunologic Factors
Previous Indexing: Chemotaxis (1966-1974); Complement (1968-1974); Neutrophils (1966-1974)
Public MeSH Note: 2006; see COMPLEMENT 7 1978-2005, see COMPLEMENT 1975-1977
History Note: 2006 (1975)
Date Established: 1978/01/01
Date of Entry: 1974/11/11
Revision Date: 2005/07/19

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0004939
Scope Note: A 93-kDa serum glycoprotein encoded by C7 gene. It is a polypeptide chain with 28 disulfide bridges. In the formation of MEMBRANE ATTACK COMPLEX; C7 is the next component to bind the C5b-6 complex forming a trimolecular complex C5b-7 which is lipophilic, resembles an integral membrane protein, and serves as an anchor for the late complement components, C8 and C9.
Terms: Complement C7 Preferred Term
Term UI T624056
Date12/14/2004
LexicalTag NON
ThesaurusID NLM (2006); C7 Complement
Term UI T631391
Date02/23/2005
LexicalTag NON
ThesaurusID NLM (2006); Complement 7
Term UI T009300
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); Complement Component 7
Term UI T624057
Date12/14/2004
LexicalTag NON
ThesaurusID NLM (2006)

Complement C7 MeSH Descriptor Data 2025