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Complement C8 MeSH Descriptor Data 2023

MeSH Heading
Complement C8
Tree Number(s)
Unique ID
RDF Unique Identifier
Scope Note
A 150-kDa serum glycoprotein composed of three subunits with each encoded by a different gene (C8A; C8B; and C8G). This heterotrimer contains a disulfide-linked C8alpha-C8gamma heterodimer and a noncovalently associated C8beta chain. C8 is the next component to bind the C5-7 complex forming C5b-8 that binds COMPLEMENT C9 and acts as a catalyst in the polymerization of C9.
Entry Term(s)
C8 Complement
Complement 8
Complement Component 8
Complement Component C8 alpha
Complement Component C8 alpha Chain
Complement Component C8 beta
Complement Component C8 beta Chain
Complement Component C8 gamma
Complement Component C8 gamma Chain
Pharm Action
Immunologic Factors
Registry Number
Previous Indexing
Bacteriolysis (1966-1974)
Complement (1968-1974)
Hemolysis (1966-1974)
Public MeSH Note
2006; see COMPLEMENT 8 1978-2005; see COMPLEMENT 1975-1977
History Note
2006 (1975)
Date Established
Date of Entry
Revision Date
Complement C8 Preferred
Complement Component C8 beta Narrower
Complement Component C8 gamma Narrower
Complement Component C8 alpha Narrower
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