MeSH Browser

MeSH Heading: Complement C8
Tree Number(s): D12.776.124.486.274.750
Unique ID: D003185
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D003185
Scope Note: A 150-kDa serum glycoprotein composed of three subunits with each encoded by a different gene (C8A; C8B; and C8G). This heterotrimer contains a disulfide-linked C8alpha-C8gamma heterodimer and a noncovalently associated C8beta chain. C8 is the next component to bind the C5-7 complex forming C5b-8 that binds COMPLEMENT C9 and acts as a catalyst in the polymerization of C9.
Entry Term(s): C8 Complement; Complement 8; Complement Component 8; Complement Component C8 alpha; Complement Component C8 alpha Chain; Complement Component C8 beta; Complement Component C8 beta Chain; Complement Component C8 gamma; Complement Component C8 gamma Chain
Pharm Action: Immunologic Factors
Previous Indexing: Bacteriolysis (1966-1974); Complement (1968-1974); Hemolysis (1966-1974)
Public MeSH Note: 2006; see COMPLEMENT 8 1978-2005; see COMPLEMENT 1975-1977
History Note: 2006 (1975)
Date Established: 1978/01/01
Date of Entry: 1974/11/11
Revision Date: 2005/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0004940
Scope Note: A 150-kDa serum glycoprotein composed of three subunits with each encoded by a different gene (C8A; C8B; and C8G). This heterotrimer contains a disulfide-linked C8alpha-C8gamma heterodimer and a noncovalently associated C8beta chain. C8 is the next component to bind the C5-7 complex forming C5b-8 that binds COMPLEMENT C9 and acts as a catalyst in the polymerization of C9.
Terms: Complement C8 Preferred Term
Term UI T624060
Date12/14/2004
LexicalTag NON
ThesaurusID NLM (2006); C8 Complement
Term UI T631392
Date02/23/2005
LexicalTag NON
ThesaurusID NLM (2006); Complement 8
Term UI T009302
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); Complement Component 8
Term UI T624061
Date12/14/2004
LexicalTag NON
ThesaurusID NLM (2006)

Complement C8 MeSH Descriptor Data 2025