MeSH Browser

MeSH Heading: Complement C9
Tree Number(s): D12.776.124.486.274.850
Unique ID: D003186
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D003186
Scope Note: A 63-kDa serum glycoprotein encoded by gene C9. Monomeric C9 (mC9) binds the C5b-8 complex to form C5b-9 which catalyzes the polymerization of C9 forming C5b-p9 (MEMBRANE ATTACK COMPLEX) and transmembrane channels leading to lysis of the target cell. Patients with C9 deficiency suffer from recurrent bacterial infections.
Entry Term(s): C9 Complement; Complement 9; Complement Component 9
Pharm Action: Immunologic Factors
Registry Number: 0
Previous Indexing: Bacteriolysis (1966-1974); Complement (1968-1974); Hemolysis (1966-1974); specific cell
Public MeSH Note: 2006; see COMPLEMENT 9 1978-2005, see COMPLEMENT 1975-1977
History Note: 2006 (1975)
Date Established: 1978/01/01
Date of Entry: 1974/11/11
Revision Date: 2005/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0004941
Registry Number: 0
Scope Note: A 63-kDa serum glycoprotein encoded by gene C9. Monomeric C9 (mC9) binds the C5b-8 complex to form C5b-9 which catalyzes the polymerization of C9 forming C5b-p9 (MEMBRANE ATTACK COMPLEX) and transmembrane channels leading to lysis of the target cell. Patients with C9 deficiency suffer from recurrent bacterial infections.
Terms: Complement C9 Preferred Term
Term UI T624064
Date12/14/2004
LexicalTag NON
ThesaurusID NLM (2006); Complement 9
Term UI T009304
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); Complement Component 9
Term UI T624065
Date12/14/2004
LexicalTag NON
ThesaurusID NLM (2006); C9 Complement
Term UI T631393
Date02/23/2005
LexicalTag NON
ThesaurusID NLM (2006)

Complement C9 MeSH Descriptor Data 2023