MeSH Browser

MeSH Heading: Complement C3-C5 Convertases
Tree Number(s): D12.776.124.486.274.045.387
Unique ID: D050577
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D050577
Scope Note: Serine proteases that cleave COMPLEMENT C3 into COMPLEMENT C3A and COMPLEMENT C3B, or cleave COMPLEMENT C5 into COMPLEMENT C5A and COMPLEMENT C5B. These include the different forms of C3/C5 convertases in the classical and the alternative pathways of COMPLEMENT ACTIVATION. Both cleavages take place at the C-terminal of an ARGININE residue.
Entry Term(s): C 3 Convertase; C3 Activator; C3 Convertase; C3-C5 Convertase; C5 Cleaving Enzyme; C5 Convertase; Complement 3 Convertase; Complement 5 Convertase; Complement C3 Convertases; Complement C5 Convertases
Pharm Action: Immunologic Factors
Registry Numbers: EC 3.4.21.-; EC 3.4.21.-; EC 3.4.21.-
Previous Indexing: Complement C3 (1976-2005); Complement C5 (1976-2005)
Public MeSH Note: 2006; for COMPLEMENT 3 CONVERTASE see COMPLEMENT 3 CONVERTASE 1991-2005, see COMPLEMENT ACTIVATING ENZYMES 1978-1990
History Note: 2006 (1978)
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2006/07/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0004929
Registry Numbers: EC 3.4.21.-
Scope Note: Serine proteases that cleaves C3 at the carboxyl of Arg-77 of the alpha-chain to yield COMPLEMENT 3A and COMPLEMENT 3B in either the classical or the alternative pathways of COMPLEMENT ACTIVATION.
Terms: Complement C3 Convertases Preferred Term
Term UI T620477
Date11/29/2004
LexicalTag NON
ThesaurusID NLM (2006); C3 Activator
Term UI T009270
Date05/17/1977
LexicalTag NON
ThesaurusID UNK (19XX); Complement 3 Convertase
Term UI T009273
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1978); C 3 Convertase
Term UI T009277
Date04/15/1981
LexicalTag NON
ThesaurusID UNK (19XX); C3 Convertase
Term UI T009278
Date05/17/1977
LexicalTag NON
ThesaurusID UNK (19XX)

Concept UI: M0476516
Registry Numbers: EC 3.4.21.-
Scope Note: Serine proteases that cleaves C5 at the carboxyl of Arg-74 of the alpha-chain to yield COMPLEMENT 5A and COMPLEMENT 5B in either the classical or the alternative pathways of COMPLEMENT ACTIVATION.
Terms: Complement C5 Convertases Preferred Term
Term UI T620478
Date11/29/2004
LexicalTag NON
ThesaurusID NLM (2006); C5 Cleaving Enzyme
Term UI T009272
Date05/04/1987
LexicalTag NON
ThesaurusID UNK (19XX); Complement 5 Convertase
Term UI T009274
Date05/04/1987
LexicalTag NON
ThesaurusID UNK (19XX); C5 Convertase
Term UI T009279
Date05/04/1987
LexicalTag NON
ThesaurusID UNK (19XX)

Complement C3-C5 Convertases MeSH Descriptor Data 2025