MeSH Browser

MeSH Heading: Complement C1s
Tree Number(s): D08.811.277.300.290; D12.776.124.486.274.045.290; D12.776.124.486.274.050.290
Unique ID: D003173
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D003173
Scope Note: A 77-kDa subcomponent of complement C1, encoded by gene C1S, is a SERINE PROTEASE existing as a proenzyme (homodimer) in the intact complement C1 complex. Upon the binding of COMPLEMENT C1Q to antibodies, the activated COMPLEMENT C1R cleaves C1s into two chains, A (heavy) and B (light, the serine protease), linked by disulfide bonds yielding the active C1s. The activated C1s, in turn, cleaves COMPLEMENT C2 and COMPLEMENT C4 to form C4b2a (CLASSICAL C3 CONVERTASE).
Entry Term(s): C 1 Esterase; C1 Esterase; C1s Complement; Complement 1 Esterase; Complement 1s; Complement Component 1s
Pharm Action: Immunologic Factors
Registry Numbers: EC 3.4.21.42
Previous Indexing: Complement 1 (1975-1977); Esterases (1966-1977)
Public MeSH Note: 2006; see COMPLEMENT 1S 1990-2005; for COMPLEMENT 1 ESTERASE see COMPLEMENT ACTIVATING ENZYMES 1978-1989
History Note: 2006 (1978)
Date Established: 1990/01/01
Date of Entry: 1977/05/16
Revision Date: 2006/07/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0004925
Registry Numbers: EC 3.4.21.42
Scope Note: A 77-kDa subcomponent of complement C1, encoded by gene C1S, is a SERINE PROTEASE existing as a proenzyme (homodimer) in the intact complement C1 complex. Upon the binding of COMPLEMENT C1Q to antibodies, the activated COMPLEMENT C1R cleaves C1s into two chains, A (heavy) and B (light, the serine protease), linked by disulfide bonds yielding the active C1s. The activated C1s, in turn, cleaves COMPLEMENT C2 and COMPLEMENT C4 to form C4b2a (CLASSICAL C3 CONVERTASE).
Terms: Complement C1s Preferred Term
Term UI T622189
Date12/07/2004
LexicalTag NON
ThesaurusID NLM (2006); Complement 1s
Term UI T009256
Date01/01/1999
LexicalTag ABX
ThesaurusID NLM (1978); C 1 Esterase
Term UI T009257
Date04/15/1981
LexicalTag NON
ThesaurusID UNK (19XX); Complement 1 Esterase
Term UI T009255
Date04/14/1989
LexicalTag NON
ThesaurusID NLM (1990); Complement Component 1s
Term UI T622190
Date12/07/2004
LexicalTag NON
ThesaurusID NLM (2006); C1s Complement
Term UI T631373
Date02/23/2005
LexicalTag NON
ThesaurusID NLM (2006); C1 Esterase
Term UI T009259
Date05/16/1977
LexicalTag NON
ThesaurusID UNK (19XX)

Complement C1s MeSH Descriptor Data 2025